Results 111 to 120 of about 168,901 (276)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

The Rise of Markov Chain Monte Carlo Estimation for Psychometric Modeling

Journal of Probability and Statistics, 2009
Markov chain Monte Carlo (MCMC) estimation strategies represent a powerful approach to estimation in psychometric models. Popular MCMC samplers and their alignment with Bayesian approaches to modeling are discussed.
Roy Levy
doaj   +1 more source

Incorporating environmental DNA metabarcoding for improved benthic biodiversity and habitat mapping

Remote Sensing in Ecology and Conservation, EarlyView.
Seafloor imagery is commonly used to collect information about the distribution of benthic organisms in order to generate habitat and biodiversity maps. Recent advances in genomics (e.g., environmental DNA; eDNA) show potential to complement video surveys for habitat mapping, but there have been few examples testing this.
Rylan J. Command, Shreya Nemani, Benjamin Misiuk, Mehrdad Hajibabaei, Nicole Fahner, Emily Porter, Greg Singer, Beverly McClenaghan, Katleen Robert   +8 more
wiley   +1 more source

Temporal Dynamics of Tourism Sustainability: Economic and Environmental Evidence From Greece

Sustainable Development, EarlyView.
ABSTRACT Tourism is a resource‐intensive sector that generates substantial economic benefits while exerting long‐term pressure on energy systems and the environment. This study examines the sustainability of tourism in Greece by analyzing how tourism growth affects economic performance, energy consumption, and carbon emissions across different time ...
Stylianou Tasos
wiley   +1 more source

BAYESIAN NEURAL NETWORK RAINFALL MODELLING: A CASE STUDY IN EAST JAVA

Barekeng
Rainfall is an important parameter in meteorology and hydrology, and it measures the amount of rain that falls from the atmosphere to the ground surface in liquid form.
Suci Astutik, Nur Silviyah Rahmi, Diego Irsandy, Fang You Dwi Ayu Shalu Saniyawati, Fidia Raaihatul Mashfia, Evelin Dewi Lusiana, Intan Fadhila Risda, Mohammad Hilmi Susanto   +7 more
doaj   +1 more source

Refinement of the Jensen integral inequality

Open Mathematics, 2016
In this paper we give a refinement of Jensen’s integral inequality and its generalization for linear functionals. We also present some applications in Information Theory.
Sever Dragomir Silvestru, Adil Khan Muhammad, Abathun Addisalem   +2 more
doaj   +1 more source

Does Economic Growth Drive Equitable Water and Sanitation Access? Assessing Inequality Reduction Across 64 Nations

Sustainable Development, EarlyView.
ABSTRACT This article examines whether economic growth reduces inequalities in access to water and sanitation across 64 countries over an average period of 13.5 years. Drawing on disaggregated data by income quintiles and rural–urban location, and employing ordinary least squares (OLS), two‐stage least squares (2SLS), and Seemingly Unrelated Regression
Marcos García‐López, Samara López‐Ruiz, Gabriela Cuadrado‐Quesada   +2 more
wiley   +1 more source

Decayed MCMC Filtering

, 2012
Filtering---estimating the state of a partially observable Markov process from a sequence of observations---is one of the most widely studied problems in control theory, AI, and computational statistics. Exact computation of the posterior distribution is generally intractable for large discrete systems and for nonlinear continuous systems, so a good ...
Marthi, Bhaskara, Pasula, Hanna, Russell, Stuart, Peres, Yuval   +3 more
openaire   +2 more sources

Energy Dependence, Energy Import Diversification, and Institutional Quality: Heterogeneous Impacts on Sustainable Economic Development in the European Union

Sustainable Development, EarlyView.
ABSTRACT Energy dependence poses significant risks for economic development, particularly in regions that rely heavily on imported fossil fuels. This paper examines how energy dependence and energy import diversification influence economic development across 27 European Union countries between 2000 and 2022. Using IV‐GMM and panel quantile regressions,
Mehmet Pinar
wiley   +1 more source