Results 31 to 40 of about 87,540 (263)

H-RT-IDPS: A Hierarchical Real-Time Intrusion Detection and Prevention System for the Smart Internet of Vehicles via TinyML-Distilled CNN and Hybrid BiLSTM-XGBoost Models

Technologies
The integration of connected vehicles into smart city infrastructure introduces critical cybersecurity challenges for the Internet of Vehicles (IoV), where resource-constrained vehicles and powerful roadside units (RSUs) must collaborate for secure ...
Ikram Hamdaoui, Chaymae Rami, Zakaria El Allali, Khalid El Makkaoui   +3 more
doaj   +1 more source

Nonlinear free vibration analysis of elastically supported carbon nanotube-reinforced composite beam with the thermal environment in non-deterministic framework

Curved and Layered Structures, 2017
This paper deals with the investigation of nonlinear free vibration behavior of elastically supported carbon nanotube reinforced composite (CNTRC) beam subjected to thermal loading with random system properties.
Chaudhari Virendra Kumar, Shegokar Niranjan L., Lal Achchhe   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Crossbreed impact of double-diffusivity convection on peristaltic pumping of magneto Sisko nanofluids in non-uniform inclined channel: A bio-nanoengineering model

Science Progress, 2021
The consequences of double-diffusivity convection on the peristaltic transport of Sisko nanofluids in the non-uniform inclined channel and induced magnetic field are discussed in this article.
Safia Akram, Maria Athar, Khalid Saeed, Alia Razia   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Temporary Mechanical Circulatory Support for Acute Myocardial Infarction Cardiogenic Shock

Methodist DeBakey Cardiovascular Journal
Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) remains a critical clinical challenge associated with high morbidity and mortality.
Saliha Erdem, Dhruvil Ashishkumar Patel, Karl Abou Zeid, Joe Aoun   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Experimental and Analytical Investigation of Deflection of R-UHPFRC Beams Subjected to Loading–Unloading

International Journal of Concrete Structures and Materials
Under service conditions, R-UHPFRC (Reinforced Ultra High Performance Fiber Reinforced Cementitious composite) beams exhibit residual deflection after loading–unloading. This is due to the tensile strain hardening behavior of UHPFRC.
Bartłomiej Sawicki, Eugen Brühwiler
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source