Results 1 to 10 of about 5,816,611 (275)

Molecular Docking and Dynamics Simulations Reveal the Potential of Anti-HCV Drugs to Inhibit COVID-19 Main Protease [PDF]

Pharmaceutical Sciences, 2021
Background: Drug repurposing is the fastest effective method to provide treatment for coronavirus disease (COVID-19). Drugs that targeting a closely related virus with similar genetic material such as hepatitis C virus (HCV) and more specifically ...
Ahmed Ali Al-Karmalawy, Radwan Alnajjar, Mohammed Dahab, Ahmed Metwaly, Ibrahim Eissa   +4 more
doaj   +1 more source

Utilization of computational methods for the identification of new natural inhibitors of human neutrophil elastase in inflammation therapy

Open Chemistry, 2023
Human neutrophil elastase (HNE) plays a crucial role in causing tissue damage in various chronic and inflammatory disorders, making it a target for treating inflammatory diseases.
Alzain Abdulrahim A., Elbadwi Fatima A., Al-Karmalawy Ahmed A., Elhag Rashid, Osman Wadah, Mothana Ramzi A.   +5 more
doaj   +1 more source

A comparative epidemiology model for understanding mental morbidity and planning health system response to the COVID-19 pandemic

Heart and Mind, 2021
Introduction: This particular coronavirus disease is a pandemic giving rise to great global affliction and uncertainty, even among those who have dedicated their lives to health care or the study of disease, or both.
David Cawthorpe
doaj   +1 more source

The Effect of Monte Carlo, Molecular Dynamic and Langevin Dynamic [PDF]

Journal of Cell and Molecular Research, 2010
Insulin-like growth factor (IGF-1) is an anti-apoptosis factor in multiple cell types associated with various cancers. Computational methods allow investigating the systems between 50–100 atoms in the frame of quantum mechanics and up to 50,000 atoms ...
Reihaneh Sabbaghzadeh, Majid Monajjemi, Fatemeh Mollaamin, Shahrbano Oryan   +3 more
doaj   +1 more source

Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs – a joint docking/molecular dynamics study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The binding mode of aromatic sulphonamides and clinically licenced drugs to the three carbonic anhydrase (CA, EC 4.2.1.1) isoforms from the human pathogen V.
Alessandro Bonardi, Alessio Nocentini, Sameh Mohamed Osman, Fatmah Ali Alasmary, Tahani Mazyad Almutairi, Dalal Saied Abdullah, Paola Gratteri, Claudiu T. Supuran   +7 more
doaj   +1 more source

MD and TEM evaluation of swift Xe ion induced latent tracks in Si₃N₄

Eurasian Journal of Physics and Functional Materials, 2021
As known silicon nitride ceramics is considered as a candidate material for inert matrix fuel hosts used for transmutation of minor actinides. Unfortunately, by now very limited data is devoted to investigate of its stability under high energy heavy ion ...
R. A. Rymzhanov, A. .. Zhalmagambetova, A. .. Ibrayeva, A. .. Janse Van Vuuren, J. H. O’Connell, V. A. Skuratov   +5 more
doaj   +1 more source

MD and TEM evaluation of swift Xe ion induced latent tracks in Si3N4 [PDF]

Eurasian Journal of Physics and Functional Materials, 2019
As known silicon nitride ceramics is considered as a candidate material for inert matrix fuel hosts used for transmutation of minor actinides. Unfortunately, by now very limited data is devoted to investigate of its stability under high energy heavy ion ...
R.A. Rymzhanov, A. Zhalmagambetova, A. Ibrayeva, A. Janse van Vuuren, J.H. O’Connell, V.A. Skuratov   +5 more
doaj   +1 more source

Joint optimisation for time consumption and energy consumption of multi-application and load balancing of cloudlets in mobile edge computing

IET Cyber-Physical Systems, 2020
Mobile edge computing (MEC) is an effective assistant technology that can overcome some defects of cloud computing. For the sake of alleviating the clashes between the capability constraint of cloudlets and the needs of mobile devices (MDs) for reducing ...
Kai Peng, Hualong Huang, Wenjie Pan, Jiabin Wang   +3 more
doaj   +1 more source

MD-2

Immunobiology, 2006
Toll-like receptors (TLRs) are a small family of type-I glycoproteins that bind to and are activated by conserved non-self molecular signatures carried by microorganisms. Toll-like receptor 4 is triggered by most lipopolysaccharides (LPS). LPS is a complex amphipathic saccharolipidic glycan derived from Gram-negative bacteria.
Alberto, Visintin, Dimitar B, Iliev, Brian G, Monks, Kristen A, Halmen, Douglas T, Golenbock   +4 more
openaire   +2 more sources

Effectiveness of Diffusion Tensor Imaging in the Microstructural Evaluation of Corpus Callosum and Brain Parenchyma in Children with Neurofibromatosis Type I

Bezmiâlem Science, 2021
Objective:To compare tractional anisotropy (FA) and mean diffusivity (MD) values obtained from corpus callosum (CC), basal ganglion, thalamus, frontal and parietal white matter in NF1 patients compared to the control group and to investigate the ...
Dilek Hacer ÇEŞME
doaj   +1 more source