MDL-001: An Oral, Direct-Acting Broad-Spectrum Antiviral for Influenza-like Illness (ILI) and Chronic Hepatitis In Vivo [PDF]
PharmaceuticalsBackground/Objectives: Endemic viral respiratory illnesses caused by influenza, RSV, and coronaviruses impose a global disease burden of hundreds of millions of infections and hundreds of thousands of deaths annually. Chronic hepatitis B and C infections
Virgil Woods +15 more
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SIRT6 activator MDL-800 alleviates periodontal inflammation by inhibiting AIM2 pathway [PDF]
Acta Pharmaceutica Sinica BPeriodontitis is an infectious and inflammatory disease. The inability to control clinical inflammation significantly contributes to unsuccessful periodontal treatment.
Peilei Shi +10 more
doaj +2 more sources
The protective role of MDL-1 in sepsis-induced lung injury: insights from a murine CLP model [PDF]
Frontiers in ImmunologyIntroductionThe Myeloid DAP12-associating lectin-1 (MDL-1) serves as a pivotal pattern recognition receptor crucial for recognizing various pathogenic microorganisms and orchestrating immune responses during infections.
Baoji Hu +8 more
doaj +2 more sources
Reducing mitochondrial dysfunction through combination therapy to limit ischemia-reperfusion injury in male DCD rats [PDF]
Frontiers in Cardiovascular MedicineIntroductionTwo predominant pathways contribute to ischemia reperfusion injury (IRI) following donation after circulatory death (DCD): mitochondrial permeability transition pore (MPTP) opening and Calpain-1 (CPN1) activation. Each pathway has established
Zachary Kiernan +6 more
doaj +2 more sources
Inflammation-targeted single-atom nanozymes drive microglial depolarization and inhibit ferroptosis via Sirt-6-xCT-GPX4 axis to attenuate early brain injury following subarachnoid hemorrhage [PDF]
Materials Today BioEarly brain injury (EBI) has been identified as a key factor leading to the poor prognosis of patients with subarachnoid hemorrhage (SAH). At present, apart from surgical treatment, there is a lack of effective neuroprotective drugs.
Boliang Liu +12 more
doaj +2 more sources
Guangtongxin yanjiu, 2022 Multiple Input Multiple Output (MIMO) detection algorithm is used to compensate the Mode Dependent Loss (MDL) in Mode Division Multiplexing (MDM) optical fiber channel.
Feng-ju FAN +4 more
doaj +1 more source
A potential role of myeloid DAP12-associating lectin (MDL)-1 in the regulation of inflammation in rheumatoid arthritis patients. [PDF]
PLoS ONE, 2014 The pathogenic roles of myeloid DAP12-associating lectin-1(MDL-1) and DAP12 in human rheumatoid arthritis (RA) remain unknown. Frequencies of MDL-1-expressing monocytes in 22 active RA patients, 16 inactive RA patients, 12 osteoarthritis (OA) patients ...
Der-Yuan Chen +7 more
doaj +1 more source
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
Acta Pharmaceutica Sinica B, 2021 Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke, but how to control the overactive neuroinflammation is still a long-standing ...
Tailin He +9 more
doaj +1 more source
A Hotspot of Subterranean Biodiversity on the Brink: Mo So Cave and the Hon Chong Karst of Vietnam
Diversity, 2023 The southern part of the Mekong Delta Limestones of Vietnam (MDL-HC or Hon Chong karst) comprises numerous small limestone hills. It is a hotspot of biodiversity for soil and cave invertebrates.
Louis Deharveng +10 more
doaj +1 more source
Economía Agraria y Recursos Naturales, 2011 En este trabajo se examina el marco regulatorio establecido por la Convención Marco sobre Cambio Climático, el Protocolo de Kioto y sus Mecanismos de Flexibilidad, entre ellos el Mecanismo de Desarrollo Limpio (MDL), y el Sistema Europeo de Comercio de ...
Ignacio Bachiller Méndez +2 more
doaj +1 more source