Results 91 to 100 of about 38,378 (273)

Patient‐Derived 3D Bioprinted Cardiac Organoid Constructs Reveal Key Pathological Features of Duchenne Muscular Dystrophy

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini, Margalida Campaner Socias, Andreas Dimopoulos, Lorenza Rinvenuto, Enrico Pozzo, Diana Stalkopf, Angelo Serafini, Sara Morri, Ashley Wang, Rita La Rovere, Yoke Chin Chai, Sveva Bollini, Geert Bultynck, H. Llewelyn Roderick, Ioannis Papantoniou, Maurilio Sampaolesi   +15 more
wiley   +1 more source

Extracting effective solutions hidden in large language models via generated comprehensive specialists: case studies in developing electronic devices

Communications Materials
Recently, the use of large-scale language models (LLMs) for generating research ideas and constructing scientific hypotheses has been gaining significant attention.
Hikari Tomita, Nobuhiro Nakamura, Shoichi Ishida, Toshio Kamiya, Kei Terayama   +4 more
doaj   +1 more source

Validation of an hplc method for the determination of 1,7-dihydroxy-2,3-methylenedioxyxanthone in extracts obtained from Polygala cyparissias A. St. Hil. & Moq. (Polygalaceae) and evaluation of the influence of its content on the gastroprotective activity

Química Nova, 2014
Polygala cyparissias is a plant widespread in Southern Latin America. Recently, we demonstrated the gastroprotective activity of the extract, as well as for one of the isolated metabolites-1,7-dihydroxy-2,3-methylenedioxyxanthone (MDX).
Luiz Carlos Klein-Júnior, Sérgio Faloni de Andrade, Valdir Cechinel-Filho, Tania Mari Bellé Bresolin   +3 more
doaj   +1 more source

Additional file 1 of Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

, 2023
Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, Rachelle H. Crosbie   +11 more
openalex   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source

Inverse‐Perovskite Ba3BO (B = Si and Ge) as a High Performance Environmentally Benign Thermoelectric Material with Low Lattice Thermal Conductivity

Advanced Science
High energy‐conversion efficiency (ZT) of thermoelectric materials has been achieved in heavy metal chalcogenides, but the use of toxic Pb or Te is an obstacle for wide applications of thermoelectricity.
Xinyi He, Shigeru Kimura, Takayoshi Katase, Terumasa Tadano, Satoru Matsuishi, Makoto Minohara, Hidenori Hiramatsu, Hiroshi Kumigashira, Hideo Hosono, Toshio Kamiya   +9 more
doaj   +1 more source

Genomic biomarkers in prostate cancer. [PDF]

, 2018
Prostate cancer is the most common non-cutaneous cancer among men in the United States. In the last decade there has been a rapid expansion in the field of biomarker assays for diagnosis, prognosis, and treatment prediction in prostate cancer.
Cooperberg, Matthew R, Feng, Felix Y, Kornberg, Zachary, Spratt, Daniel E   +3 more
core  

Trees and asymptotic developments for fractional stochastic differential equations [PDF]

, 2006
In this paper we consider a n-dimensional stochastic differential equation driven by a fractional Brownian motion with Hurst parameter H>1/3. After solving this equation in a rather elementary way, following the approach of Gubinelli, we show how to ...
Neuenkirch, Andreas, Nourdin, Ivan, Rößler, Andreas, Tindel, Samy   +3 more
core   +4 more sources

Dystrophin expression in the mdx mouse restored by stem cell transplantation [PDF]

, 1999
Emanuela Gussoni, Yuko Soneoka, Corinne D. Strickland, Elizabeth A. Buzney, Mohamed K. Khan, Alan F. Flint, Louis M. Kunkel, Richard C. Mulligan   +7 more
openalex   +1 more source

Wnt7a is required for regeneration of dystrophic skeletal muscle

Skeletal Muscle
Intramuscular injection of Wnt7a has been shown to accelerate and augment skeletal muscle regeneration and to ameliorate dystrophic progression in mdx muscle, a model for Duchenne muscular dystrophy (DMD).
Uxia Gurriaran-Rodriguez, Kasun Kodippili, David Datzkiw, Ehsan Javandoost, Fan Xiao, Maria Teresa Rejas, Michael A. Rudnicki   +6 more
doaj   +1 more source