Results 31 to 40 of about 38,378 (273)

Improving translational studies: lessons from rare neuromuscular diseases [PDF]

, 2015
Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are ...
Wells, D J
core   +3 more sources

Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy [PDF]

, 2016
Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a ...
Hildyard, J C W, Wells, D J
core   +1 more source

Thermoelectric performance enhancement of environmentally‐friendly SrTiO3 epitaxial films by hydrogen substitution

EcoEnergy
Developing high‐efficiency and environmentally‐friendly thermoelectric materials has been a significant challenge. Conventional thermometric materials consist of heavy (toxic) elements to reduce thermal conductivity (κ), while we demonstrated light ...
Masatoshi Kimura, Masahiro Ochiai, Xinyi He, Takayoshi Katase, Hidenori Hiramatsu, Hideo Hosono, Toshio Kamiya   +6 more
doaj   +1 more source

Langerhans Cell Histiocytosis Presenting as Uncontrolled Asthma

Case Reports in Medicine, 2013
Langerhans cell histiocytosis (LCH) is an uncommon disorder affecting primarily young adult smokers. It is characterized by abnormal proliferation of Langerhans cells, specialized monocyte-macrophage lineage antigen-presenting cells.
Frederic A. Rawlins, James E. Hull, Julia A. Morgan, Michael J. Morris   +3 more
doaj   +1 more source

Data on protein abundance alteration induced by chronic exercise in mdx mice model of Duchenne muscular dystrophy and potential modulation by apocynin and taurine

Data in Brief, 2018
Here we present original data related to the research paper entitled “Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of Key Metabolic and Contractile Proteins after chronic exercise and the potential modulation by anti ...
Tania Gamberi, Tania Fiaschi, Elisa Valocchia, Alessandra Modesti, Paola Mantuano, Jean-Francois Rolland, Francesca Sanarica, Annamaria De Luca, Francesca Magherini   +8 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Effects of nitrogen vacancy sites of oxynitride support on the catalytic activity for ammonia decomposition

NPG Asia Materials
Nitrogen-containing compounds such as imides and amides have been reported as efficient materials that promote ammonia decomposition over nonnoble metal catalysts.
Kazuki Miyashita, Kiya Ogasawara, Masayoshi Miyazaki, Hitoshi Abe, Yasuhiro Niwa, Hideki Kato, Hideo Hosono, Masaaki Kitano   +7 more
doaj   +1 more source

Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse.

PLoS ONE, 2010
Thymosin beta-4 (Tbeta4) is a ubiquitous protein with many properties relating to cell proliferation and differentiation that promotes wound healing and modulates inflammatory mediators.
Christopher F Spurney, Hee-Jae Cha, Arpana Sali, Gouri S Pandey, Emidio Pistilli, Alfredo D Guerron, Heather Gordish-Dressman, Eric P Hoffman, Kanneboyina Nagaraju   +8 more
doaj   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

MDX-MYCIN: The MDX paradigm applied to the mycin domain

Computers & Mathematics with Applications, 1985
AbstractComparison of different approaches to expert system design for a given task, such as diagnosis, is difficult since they are eoften embodied in systems for domains with very different characteristics. It is a priori difficult to decide if a given difference in the approaches is necessitated by the differences in the domain. For example, it might
Sticklen, Jon, Chadrasekaran, B., Smith, J.W., Svirbely, John   +3 more
openaire   +1 more source