Results 1 to 10 of about 1,104,554 (244)

Quantitative T2 combined with texture analysis of nuclear magnetic resonance images identify different degrees of muscle involvement in three mouse models of muscle dystrophy: mdx, Largemyd and mdx/Largemyd.

PLoS ONE, 2015
Quantitative nuclear magnetic resonance imaging (MRI) has been considered a promising non-invasive tool for monitoring therapeutic essays in small size mouse models of muscular dystrophies.
Aurea B Martins-Bach, Jackeline Malheiros, Béatrice Matot, Poliana C M Martins, Camila F Almeida, Waldir Caldeira, Alberto F Ribeiro, Paulo Loureiro de Sousa, Noura Azzabou, Alberto Tannús, Pierre G Carlier, Mariz Vainzof   +11 more
doaj   +2 more sources

GsMTx4-D provides protection to the D2.mdx mouse. [PDF]

Neuromuscul Disord, 2018
Ward CW, Sachs F, Bush ED, Suchyna TM.
europepmc   +4 more sources

Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations. [PDF]

FASEB J
We sought to determine a causal role for the microbiota in promoting dystrophic muscle characteristics by performing intra/inter‐genotype fecal microbiota transplantations (FMT) between wildtype (C57BL/10) and mdx (C57BL/10ScSn‐Dmdmdx/J) mice. We found that transplantation of mdx microbiotas into a wildtype mouse induced an mdx‐like muscle phenotype ...
Butcher J, Gosse JT, Gobin J, Ravel-Chapuis A, Jasmin BJ, Stintzi A.   +5 more
europepmc   +2 more sources

Cognitive impairment appears progressive in the mdx mouse.

Neuromuscul Disord, 2020
Bagdatlioglu E, Porcari P, Greally E, Blamire AM, Straub VW.   +4 more
europepmc   +2 more sources

Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice

iScience, 2022
Summary: The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in ...
Riley E.G. Cleverdon, Jessica L. Braun, Mia S. Geromella, Kennedy C. Whitley, Daniel M. Marko, Sophie I. Hamstra, Brian D. Roy, Rebecca E.K. MacPherson, Val A. Fajardo   +8 more
doaj   +1 more source

Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy

Human Gene Therapy, 2021
Duchenne muscular dystrophy (DMD) is a rare, X-linked, fatal, degenerative neuromuscular disease caused by mutations in the DMD gene. More than 2,000 mutations of the DMD gene are responsible for progressive loss of muscle strength, loss of ambulation ...
R. Potter, D. Griffin, K. Heller, E. Peterson, E. K. Clark, J. Mendell, L. Rodino-Klapac   +6 more
semanticscholar   +1 more source

Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. [PDF]

PLoS ONE, 2015
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (DMD), but none of these approaches have led to significant long-term effects in patients.
Kelly M Gutpell, William T Hrinivich, Lisa M Hoffman   +2 more
doaj   +1 more source

Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression. [PDF]

, 2014
Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz ...
A Gur, A Stergioulas, AP Gautam, B Hegedus, BJ Barber, CF Rizzi, CR Hayworth, D Avni, DE Lebel, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, EC Leal Junior, Ernesto Cesar Pinto Leal-Junior, F Aimbire, F Aimbire, F Serra, GD Thomas, GF Cox, JA Goldman, Jan Magnus Bjordal, JK McGeachie, JM Bjordal, Jon Joensen, JR Basford, JS Chamberlain, KS Ramaswamy, Lucio Frigo, M Koenig, M Li, M Tullberg, Mark I. Johnson, Maurilio Sampaolesi, MM Schubert, O Ozcelik, P de Almeida, P de Almeida, Patrícia de Almeida, Paulo de Tarso Camillo de Carvalho, PC Silveira, R Albertini, R Albertini, RJ Fairclough, Rodrigo Álvaro Brandão Lopes-Martins, RT Chow, RT Chow, S Rao, S Rochkind, Shaiane Silva Tomazoni, T De Marchi, T Takema, TA Partridge, V Ricotti, W Lim, X Xu, Y Lampl, Y Moriyama, YY Huang   +60 more
core   +19 more sources

Assessment of Behavioral Characteristics With Procedures of Minimal Human Interference in the mdx Mouse Model for Duchenne Muscular Dystrophy

Frontiers in Behavioral Neuroscience, 2021
Duchenne muscular dystrophy (DMD) is a severe, progressive neuromuscular disorder caused by mutations in the DMD gene resulting in loss of functional dystrophin protein.
S. Engelbeen, A. Aartsma-Rus, B. Koopmans, M. Loos, M. van Putten   +4 more
semanticscholar   +1 more source

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice [PDF]

, 2015
Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the
Berardinelli, Maria Grazia, Camilli, Carlotta, Catizone, Angela, De Benedetti, Fabrizio, Forcina, Laura, Musarò, Antonio, Nicoletti, Carmine, Pelosi, Laura, Rizzuto, Emanuele, Spelta, Elisa, Testa, Erika   +10 more
core   +2 more sources