Results 101 to 110 of about 1,104,554 (244)

Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction‐induced loss of force‐producing capacity

Journal of Physiology, 2019
Adeno‐associated viral vector was used to elevate the expression of muscle specific kinase (MuSK) and rapsyn (a cytoplasmic MuSK effector protein) in the tibialis anterior muscle of wild‐type and dystrophic (mdx) mice. In mdx mice, enhanced expression of
S. Trajanovska, J. Ban, J. Huang, P. Gregorevic, M. Morsch, D. Allen, W. Phillips   +6 more
semanticscholar   +1 more source

Dose‐ and Duration‐Dependent Effects of Propylene Glycol on Lipid Metabolism‐Related mRNAs, Proteins, and Fatty Acids in the Adipose Tissue of Fattening Akkaraman Lambs

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Propylene glycol modulated lipid metabolism in gluteal fat tissue. Expression of FABP4 at Day 60 and 120, and PPARγ and C/EBPα at Day 120 were upregulated, while SREBP1c was downregulated at both the mRNA (Day 120) and protein levels (Day 60 and 120).
Akın Yakan, Hüseyin Özkan, Hasan Hüseyin Keçeli, Ufuk Kaya, Irem Karaaslan, Sevda Dalkiran, Necmettin Ünal, Baran Çamdeviren, Güven Güngör, Mehmet Küçükoflaz, Savaş Sariözkan, Korhan Arslan, Bilal Akyüz, Aytaç Akçay, Ceyhan Özbeyaz   +14 more
wiley   +1 more source

A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice. [PDF]

, 2001
Dystrophin-deficient muscles experience large reductions in expression of nitric oxide synthase (NOS), which suggests that NO deficiency may influence the dystrophic pathology.
Spencer, MJ, Tidball, JG, Wehling, M
core  

Fast Myosin Binding Protein‐C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast‐twitch muscle fibres are characterized by their rapid contraction kinetics, high‐force generation and a distinct gene expression profile compared to slow‐twitch fibres.
Akhil Baby, Kalyani Ananthamohan, Brenna N. McIntyre, Sankar Natesan, Taejeong Song   +4 more
wiley   +1 more source

Prmt5 is a regulator of muscle stem cell expansion in adult mice. [PDF]

, 2015
Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling the fate of MuSC is missing.
Braun, Thomas, Günther, Stefan, Kim, Johnny, Krüger, Marcus, Künne, Carsten, Looso, Mario, Zhang, Ting, Zhou, Yonggang   +7 more
core  

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec, Yeranuhi Hovhannisyan, Gaëlle Revet, Sila Polat, Medhi Hassani, Nathalie Mougenot, Inès Barthelemy, Stephane Blot, Caroline Cieniewski‐Bernard, Arnaud Ferry, Ekaterini Kordeli, Zhenlin Li, Onnik Agbulut   +12 more
wiley   +1 more source

Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin-2 [PDF]

, 2017
New Findings: What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD).
Brannock, Molly, Burns, David P., Canavan, Leonie, Edge, Deirdre, Murphy, Kevin H., O'Halloran, Ken D., O'Malley, Dervla, Rowland, Jane   +7 more
core   +1 more source

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Skeletal Muscle, 2017
BackgroundThe treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for therapies that benefit all patients
Michael St. Andre, Mark Johnson, Prashant N. Bansal, J. Wellen, A. Robertson, A. Opsahl, P. Burch, P. Bialek, C. Morris, J. Owens   +9 more
semanticscholar   +1 more source

A 107 Gene Nanostring Assay Effectively Translates the Cancer Genome Atlas, and Tumour Microenvironment Gastric Cancer Molecular Classification to a Patient‐Derived Organoid Model

Genes, Chromosomes and Cancer, Volume 64, Issue 11, November 2025.
ABSTRACT There is a need to improve the translation of gastric cancer molecular classification schemes, such as those proposed by the Cancer Genome Atlas (TCGA) and Tumour Microenvironment score (TME), to clinical specimens and three‐dimensional organoid culture models.
D. Skubleny, K. Purich, T. Williams, D. R. McLean, S. N. Martins‐Filho, K. Buttenschoen, E. Haase, M. McCall, K. Baker, S. Ghosh, J. L. Spratlin, D. E. Schiller, G. R. Rayat   +12 more
wiley   +1 more source

Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging

Journal of Cardiovascular Magnetic Resonance, 2009
Background Duchenne muscular dystrophy (DMD) is caused by the absence of the cytoskeletal protein, dystrophin. In DMD patients, dilated cardiomyopathy leading to heart failure may occur during adolescence. However, early cardiac dysfunction is frequently
Zhong Jia, Liu Wei, Li Wei, Yu Xin
doaj   +1 more source