Results 131 to 140 of about 1,104,554 (244)

Benefits of Prenatal Taurine Supplementation in Preventing the Onset of Acute Damage in the Mdx Mouse

PLOS Currents, 2017
Introduction: Duchenne Muscular Dystrophy (DMD) is a debilitating muscle wasting disorder with no cure. Safer supplements and therapies are needed to improve the severity of symptoms, as severe side effects are associated with the only effective ...
R. G. Barker, Deanna M. Horvath, C. van der Poel, R. Murphy   +3 more
semanticscholar   +1 more source

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

Neurobiology of Disease, 2008
This review discusses various issues to consider when developing standard operating procedures for pre-clinical studies in the mdx mouse model of Duchenne muscular dystrophy (DMD).
Miranda D. Grounds, Hannah G. Radley, Gordon S. Lynch, Kanneboyina Nagaraju, Annamaria De Luca   +4 more
doaj   +1 more source

Altered social behavior and ultrasonic communication in the dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy

Molecular Autism, 2015
BackgroundThe Duchenne and Becker muscular dystrophies (DMD, BMD) show significant comorbid diagnosis for autism, and the genomic sequences encoding the proteins responsible for these diseases, the dystrophin and associated proteins, have been proposed ...
R. Miranda, Flora Nagapin, Bruno Bozon, S. Laroche, T. Aubin, C. Vaillend   +5 more
semanticscholar   +1 more source

Live‐imaging of revertant and therapeutically restored dystrophin in the Dmd^EGFP‐mdx mouse model for Duchenne muscular dystrophy [PDF]

, 2020
Mina Petkova, Amalia Stantzou, A. Morin, Olga N. Petrova, Susanne Morales-Gonzalez, Franziska Seifert, J. Bellec-Dyèvre, Tudor Manoliu, Aurélie Goyenvalle, Laurynn Garcia, Isabelle Richard, Corinne Laplace‐Builhé, Markus Schuelke, Helge Amthor   +13 more
openalex   +1 more source

Brain glucose metabolism as a neuronal substrate of the abnormal behavioral response to stress in the mdx mouse, a model of Duchenne muscular dystrophy

Neurobiology of Disease
Duchenne muscular dystrophy (DMD) is associated with a range of cognitive and behavioral problems. Brain-related comorbidities show clinical heterogeneity depending on the position of the mutation within the multi-promoter dystrophin (DMD) gene, likely ...
Sébastien Goutal, Marion Lancien, François Rivier, Nicolas Tournier, Cyrille Vaillend   +4 more
doaj   +1 more source

Galectin-1 Protein Therapy Prevents Pathology and Improves Muscle Function in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Molecular Therapy, 2015
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex.
Pam M Van Ry, R. Wuebbles, Megan Key, D. Burkin   +3 more
semanticscholar   +1 more source

573. Enhanced Level of Gene Correction Mediated by Oligonucleotides Containing CpG Modification in the mdx Mouse Model for Duchenne Muscular Dystrophy [PDF]

, 2006
Carmen Bertoni, Arjun Rustagi, Thomas A. Rando   +2 more
openalex   +1 more source

PKC theta ablation improves healing in a mouse model of muscular dystrophy.

PLoS ONE, 2012
Inflammation is a key pathological characteristic of dystrophic muscle lesion formation, limiting muscle regeneration and resulting in fibrotic and fatty tissue replacement of muscle, which exacerbates the wasting process in dystrophic muscles.
Luca Madaro, Andrea Pelle, Carmine Nicoletti, Annunziata Crupi, Valeria Marrocco, Gianluca Bossi, Silvia Soddu, Marina Bouché   +7 more
doaj   +1 more source

Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers

Molecules, 2015
The primary deficiency in the membrane cytoskeletal protein dystrophin results in complex changes in dystrophic muscles. In order to compare the degree of secondary alterations in differently affected subtypes of skeletal muscles, we have conducted a ...
A. Holland, M. Henry, P. Meleady, Claudia K. Winkler, Mirjam Krautwald, H. Brinkmeier, K. Ohlendieck   +6 more
semanticscholar   +1 more source

P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment [PDF]

, 2011
Chris Young, Wojciech Brutkowski, Chun‐Fu Lien, S. Arkle, Hanns Lochmüller, Krzysztof Zabłocki, Dariusz C. Górecki   +6 more
openalex   +1 more source