Results 131 to 140 of about 18,188 (219)

Respiratory pathology in the mdx/utrn -/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD).

PLoS ONE
Duchenne muscular dystrophy (DMD) is an X-linked devastating disease caused by a lack of dystrophin which results in progressive muscle weakness. As muscle weakness progresses, respiratory insufficiency and hypoventilation result in significant morbidity
Marán Y Hernández Rodríguez, Debolina D Biswas, Aoife D Slyne, Jane Lee, Evelyn Scarrow, Sarra M Abdelbarr, Heather Daniels, Ken D O'Halloran, Leonardo F Ferreira, Charles A Gersbach, Mai K ElMallah   +10 more
doaj   +1 more source

Mineralocorticoid receptor antagonists reduce inflammatory signaling independent of myofiber mineralocorticoid receptor

Endocrine and Metabolic Science
Chronic inflammation is a feature of Duchenne muscular dystrophy (DMD), a degenerative striated muscle disease. Mineralocorticoid receptor (MR) antagonists (MRAs) have demonstrated clinical benefit on later onset DMD cardiomyopathy, and preclinical ...
Jeovanna Lowe, Arden B. Piepho, Chetan K. Gomatam, Peyton Debell, Megan N. Ballinger, Jill A. Rafael-Fortney   +5 more
doaj   +1 more source

Partial Restoration of Brain Dystrophin and Behavioral Deficits by Exon Skipping in the Muscular Dystrophy X-Linked (mdx) Mouse. [PDF]

Ann Neurol, 2022
Zarrouki F, Relizani K, Bizot F, Tensorer T, Garcia L, Vaillend C, Goyenvalle A.   +6 more
europepmc   +1 more source

Six weeks of N-acetylcysteine antioxidant in drinking water decreases pathological fiber branching in MDX mouse dystrophic fast-twitch skeletal muscle. [PDF]

Front Physiol, 2023
Redwan A, Kiriaev L, Kueh S, Morley JW, Houweling P, Perry BD, Head SI.   +6 more
europepmc   +1 more source

Characterisation of Progressive Skeletal Muscle Fibrosis in the Mdx Mouse Model of Duchenne Muscular Dystrophy: An In Vivo and In Vitro Study. [PDF]

Int J Mol Sci, 2022
Giovarelli M, Arnaboldi F, Zecchini S, Cornaghi LB, Nava A, Sommariva M, Clementi EGI, Gagliano N.   +7 more
europepmc   +1 more source

Sunitinib inhibits STAT3 phosphorylation in cardiac muscle and prevents cardiomyopathy in the mdx mouse model of Duchenne muscular dystrophy. [PDF]

Hum Mol Genet, 2022
Oliveira-Santos A, Dagda M, Burkin DJ.
europepmc   +1 more source

Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model. [PDF]

BMC Cardiovasc Disord, 2021
Sullivan RT, Lam NT, Haberman M, Beatka MJ, Afzal MZ, Lawlor MW, Strande JL.   +6 more
europepmc   +1 more source

Cell surface and gene expression regulation molecules in dystrophinopathy: mdx vs. Duchenne

Biological Research, 2005
Duchenne muscular dystrophy (DMD) is secondary to loss-of-function mutations in the dystrophin gene. The causes underlying the progression of DMD, differential muscle involvement, and the discrepancies in phenotypes among species with the same genetic ...
RICARDO FADIC
doaj  

Co-Administration of Simvastatin Does Not Potentiate the Benefit of Gene Therapy in the mdx Mouse Model for Duchenne Muscular Dystrophy. [PDF]

Int J Mol Sci, 2022
Bourg N, Vu Hong A, Lostal W, Jaber A, Guerchet N, Tanniou G, Bordier F, Bertil-Froidevaux E, Georger C, Daniele N, Richard I, Israeli D.   +11 more
europepmc   +1 more source

Growth hormone secretagogues modulate inflammation and fibrosis in <i>mdx</i> mouse model of Duchenne muscular dystrophy. [PDF]

Front Immunol, 2023
Boccanegra B, Cappellari O, Mantuano P, Trisciuzzi D, Mele A, Tulimiero L, De Bellis M, Cirmi S, Sanarica F, Cerchiara AG, Conte E, Meanti R, Rizzi L, Bresciani E, Denoyelle S, Fehrentz JA, Cruciani G, Nicolotti O, Liantonio A, Torsello A, De Luca A.   +20 more
europepmc   +1 more source