Results 11 to 20 of about 9,256 (223)

Human Galectin-1 Improves Sarcolemma Stability and Muscle Vascularization in the mdx Mouse Model of Duchenne Muscular Dystrophy [PDF]

Molecular Therapy: Methods & Clinical Development, 2019
Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the dystrophin gene that result in the complete absence of dystrophin protein.
Ryan D. Wuebbles, Vivian Cruz, Pam Van Ry, Pamela Barraza-Flores, Paul D. Brewer, Peter Jones, Dean J. Burkin   +6 more
doaj   +2 more sources

Characterization of Alzheimer's disease‐like neuropathology in Duchenne's muscular dystrophy using the DBA/2J mdx mouse model [PDF]

FEBS Open Bio, 2022
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder caused by a mutation in the dystrophin gene. In addition to muscle pathology, some patients with DMD will exhibit cognitive impairments with severity being linked to age and type ...
Grant C. Hayward, Daniela Caceres, Emily N. Copeland, Bradley J. Baranowski, Ahmad Mohammad, Kennedy C. Whitley, Val A. Fajardo, Rebecca E. K. MacPherson   +7 more
doaj   +2 more sources

Quantitative T2 combined with texture analysis of nuclear magnetic resonance images identify different degrees of muscle involvement in three mouse models of muscle dystrophy: mdx, Largemyd and mdx/Largemyd.

PLoS ONE, 2015
Quantitative nuclear magnetic resonance imaging (MRI) has been considered a promising non-invasive tool for monitoring therapeutic essays in small size mouse models of muscular dystrophies.
Aurea B Martins-Bach, Jackeline Malheiros, Béatrice Matot, Poliana C M Martins, Camila F Almeida, Waldir Caldeira, Alberto F Ribeiro, Paulo Loureiro de Sousa, Noura Azzabou, Alberto Tannús, Pierre G Carlier, Mariz Vainzof   +11 more
doaj   +2 more sources

Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Duchenne muscular dystrophy (DMD) is a devastating disease characterized by progressive muscle wasting that leads to diminished lifespan. In addition to the inherent weakness of dystrophin‐deficient muscle, the dysfunction of resident muscle ...
Marie E. Esper, Caroline E. Brun, Alexander Y. T. Lin, Peter Feige, Marie J. Catenacci, Marie‐Claude Sincennes, Morten Ritso, Michael A. Rudnicki   +7 more
doaj   +2 more sources

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy. [PDF]

J Physiol
Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Mattina SR, Ng SY, Mikhail AI, Stouth DW, Jornacion CE, Rebalka IA, Hawke TJ, Ljubicic V.   +7 more
europepmc   +2 more sources

Determination of qPCR reference genes suitable for normalizing gene expression in a novel model of Duchenne muscular dystrophy, the D2-mdx mouse. [PDF]

PLoS ONE
Duchenne muscular dystrophy (DMD) is a X-linked neuromuscular disorder arising from mutations in the dystrophin gene, leading to a progressive muscle wasting and disability.
Brigida Boccanegra, Roberta Lenti, Paola Mantuano, Elena Conte, Lisamaura Tulimiero, Richard J Piercy, Ornella Cappellari, John C W Hildyard, Annamaria De Luca   +8 more
doaj   +2 more sources

Chronic N‐acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy [PDF]

Experimental Physiology
Duchenne muscular dystrophy (DMD) is characterised by respiratory muscle injury, inflammation, fibrosis and weakness, ultimately culminating in respiratory failure.
Michael N. Maxwell, Anthony L. Marullo, Esther Valverde‐Pérez, Aoife D. Slyne, Ben T. Murphy, Ken D. O'Halloran   +5 more
doaj   +2 more sources

IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse [PDF]

BMC Musculoskeletal Disorders, 2012
Background IL-6 is a pleiotropic cytokine that modulates inflammatory responses and plays critical roles in muscle maintenance and remodeling. In the mouse model (mdx) of Duchenne Muscular Dystrophy, IL-6 and muscle inflammation are elevated, which is ...
Kostek Matthew C, Nagaraju Kanneboyina, Pistilli Emidio, Sali Arpana, Lai San-Huei, Gordon Brad, Chen Yi-Wen   +6 more
doaj   +2 more sources

Six weeks of N-acetylcysteine antioxidant in drinking water decreases pathological fiber branching in MDX mouse dystrophic fast-twitch skeletal muscle. [PDF]

Front Physiol, 2023
Redwan A, Kiriaev L, Kueh S, Morley JW, Houweling P, Perry BD, Head SI.   +6 more
europepmc   +3 more sources

Lipocalin 2 Influences Bone and Muscle Phenotype in the MDX Mouse Model of Duchenne Muscular Dystrophy. [PDF]

Int J Mol Sci, 2022
Ponzetti M, Ucci A, Maurizi A, Giacchi L, Teti A, Rucci N.   +5 more
europepmc   +3 more sources