GsMTx4-D provides protection to the D2.mdx mouse. [PDF]
Neuromuscul Disord, 2018 Duchenne muscular dystrophy is a life-limiting muscle disease that has no current effective therapy. Despite mounting evidence that dysregulation of mechanosensitive ion channels is a significant contributor to dystrophy pathogenesis, effective pharmacologic strategies targeting these channels are lacking.
Ward CW, Sachs F, Bush ED, Suchyna TM.
europepmc +7 more sources
Humanizing the mdx mouse model of DMD: the long and the short of it. [PDF]
NPJ Regen Med, 2018 Duchenne muscular dystrophy (DMD) is a common fatal heritable myopathy, with cardiorespiratory failure occurring by the third decade of life. There is no specific treatment for DMD cardiomyopathy, in large part due to a lack of understanding of the ...
Yucel N +4 more
europepmc +8 more sources
Visual Discrimination, Serial Reversal, and Extinction Learning in the mdx Mouse [PDF]
Frontiers in Behavioral Neuroscience, 2019 Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy and the most common neuromuscular disorder. In addition to neuromuscular consequences, some individuals with DMD experience global intellectual dysfunction and executive ...
Price E. Dickson, Guy Mittleman
doaj +4 more sources
Cognitive impairment appears progressive in the mdx mouse. [PDF]
Neuromuscul Disord, 2020 Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease caused by mutations in the DMD gene, which encodes the large cytoskeletal protein dystrophin. Approximately one-third of DMD patient's exhibit cognitive problems yet it is unknown if cognitive impairments worsen with age.
Bagdatlioglu E +4 more
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Integrative effects of dystrophin loss on metabolic function of the mdx mouse. [PDF]
Sci Rep, 2018 Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin.
Strakova J +7 more
europepmc +6 more sources
Determination of qPCR reference genes suitable for normalizing gene expression in a novel model of Duchenne muscular dystrophy, the D2-mdx mouse. [PDF]
PLoS ONEDuchenne muscular dystrophy (DMD) is a X-linked neuromuscular disorder arising from mutations in the dystrophin gene, leading to a progressive muscle wasting and disability.
Brigida Boccanegra +8 more
doaj +2 more sources
Moderate exercise improves function and increases adiponectin in the mdx mouse model of muscular dystrophy. [PDF]
Sci Rep, 2019 The loss of dystrophin produces a mechanically fragile sarcolemma, causing muscle membrane disruption and muscle loss. The degree to which exercise alters muscular dystrophy has been evaluated in humans with Duchenne Muscular Dystrophy (DMD) and in mouse
Zelikovich AS +4 more
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Chronic N‐acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy [PDF]
Experimental PhysiologyDuchenne muscular dystrophy (DMD) is characterised by respiratory muscle injury, inflammation, fibrosis and weakness, ultimately culminating in respiratory failure.
Michael N. Maxwell +5 more
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Eosinophils Do Not Drive Acute Muscle Pathology in the mdx Mouse Model of Duchenne Muscular Dystrophy. [PDF]
J Immunol, 2019 Key Points Eosinophils are prominent in quadriceps lesions of dystrophin-deficient mdx mice. Muscle damage was evaluated quantitatively in mdx, mdx.PHIL, and mdx.IL5tg mice.
Sek AC +8 more
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The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse. [PDF]
Sci Rep, 2019 The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis.
Bahri OA +5 more
europepmc +2 more sources