Results 221 to 230 of about 1,087,549 (254)

Somatic reversion/suppression of the mouse mdx phenotype in vivo

Journal of the Neurological Sciences, 1990
The mdx mouse has a myopathy caused by dystrophin deficiency, and is therefore biochemically and genetically homologous to human Duchenne muscular dystrophy. While mdx mouse muscle shows no dystrophin by immunoblotting, a very small percentage of myofibers appear clearly dystrophin-positive by immunofluorescence microscopy.
J. E. Morgan, Simon C. Watkins, T. A. Partridge, Eric P. Hoffman   +3 more
openaire   +3 more sources

Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings

Neuromuscular Disorders, 2004
Heart failure is a major cause of death in boys with Duchenne muscular dystrophy. In order to determine if the cardiac function of the mdx mouse is similarly disturbed, we performed murine echocardiograms and left heart catheterization studies, along with morphometric analysis of cardiac fibrosis.
John N. Lorenz, Linda Levin, John G. Quinlan, Alexandra Wenisch, Brenda Wong, Harvey S. Hahn   +5 more
openaire   +3 more sources

Fasting Increases the Extent of Muscle Necrosis in the mdx Mouse

Clinical Science, 1996
1. The effects of fasting for 48 h were investigated in CS7BL/10 (wild type) and age-matched C57BL/10 dystrophin-deficient (mdx) mice. 2. Fasting resulted in an increased percentage of necrotic fibres in muscles from the hindlimb and lumbar regions of mdx mice.
Rht Edwards, PA MacLennan, Anne McArdle, Timothy R. Helliwell, Malcolm J. Jackson   +4 more
openaire   +3 more sources

Pre-clinical study of 21 approved drugs in the mdx mouse

Neuromuscular Disorders, 2011
Duchenne muscular dystrophy, a genetic disease caused by the absence of functional dystrophin, remains without adequate treatment. Although great hopes are attached to gene and cell therapies, identification of active small molecules remains a valid option for new treatments.
Carre-Pierrat, M., Lafoux, A., Tanniou, G., Chambonnier, L., Divet, A., Fougerousse, F., Huchet-Cadiou, C., Segalat, L.   +7 more
openaire   +5 more sources

Reduced neuronal density in the CA1 anterodorsal hippocampus of the mdx mouse

Neuromuscular Disorders, 2016
Duchenne muscular dystrophy (DMD) is associated with non-progressive cognitive dysfunction including hippocampal-dependent memory deficits. Loss of the cytoskeleton-associated dystrophin protein in central inhibitory synapses, associated with consequent alterations in GABAergic function and synaptic plasticity, has been proposed as a primary mechanism ...
Miranda, Rubén, Laroche, Serge, Vaillend, Cyrille   +2 more
openaire   +3 more sources

Therapeutic screening in the mdx mouse

Neuromuscular Disorders, 2000
CONTE, Diana, DE LUCA, Annamaria
openaire   +4 more sources

Is cognitive impairment progressive in the mdx mouse?

Neuromuscular Disorders, 2017
V. Straub, E Bagdatlioglu, A. Roos, E. Greally, Paola Porcari, Andrew M. Blamire   +5 more
openaire   +2 more sources

Effects of diltiazem and dantrolene in the mdx mouse

Neuromuscular Disorders, 1996
M. Freilinger, H. Höger, K. Herkner, Reginald E. Bittner, E. Hauser, K. Widhalm   +5 more
openaire   +2 more sources

DNA concentrations are increased in MDX mouse muscles

Biochemical Society Transactions, 1991
Richard H.T. Edwards, PA MacLennan, Malcolm J. Jackson   +2 more
openaire   +3 more sources

Expanded encyclopaedias of DNA elements in the human and mouse genomes

Nature, 2020
Jessika Adrian, Michael A Beer, Bradley E Bernstein   +2 more
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