Human Galectin-1 Improves Sarcolemma Stability and Muscle Vascularization in the mdx Mouse Model of Duchenne Muscular Dystrophy [PDF]
Molecular Therapy: Methods & Clinical Development, 2019 Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the dystrophin gene that result in the complete absence of dystrophin protein.
Ryan D. Wuebbles +6 more
doaj +2 more sources
Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Duchenne muscular dystrophy (DMD) is a devastating disease characterized by progressive muscle wasting that leads to diminished lifespan. In addition to the inherent weakness of dystrophin‐deficient muscle, the dysfunction of resident muscle ...
Marie E. Esper +7 more
doaj +2 more sources
Exploring the respiratory efficacy of combined chronic glucocorticoid and antioxidant interventions in the mdx mouse: The PREDNAC trial. [PDF]
Exp PhysiolAbstract Duchenne muscular dystrophy (DMD) is characterized by respiratory muscle injury and weakness, ultimately leading to respiratory failure. Impaired respiratory muscle performance, fibrosis and inflammation in early disease are evident in the dystrophin‐deficient mdx mouse model of DMD.
Maxwell MN +3 more
europepmc +2 more sources
Determination of qPCR reference genes suitable for normalizing gene expression in a novel model of Duchenne muscular dystrophy, the D2-mdx mouse. [PDF]
PLoS ONEDuchenne muscular dystrophy (DMD) is a X-linked neuromuscular disorder arising from mutations in the dystrophin gene, leading to a progressive muscle wasting and disability.
Brigida Boccanegra +8 more
doaj +2 more sources
Humanizing the mdx mouse model of DMD: the long and the short of it. [PDF]
NPJ Regen Med, 2018 Duchenne muscular dystrophy (DMD) is a common fatal heritable myopathy, with cardiorespiratory failure occurring by the third decade of life. There is no specific treatment for DMD cardiomyopathy, in large part due to a lack of understanding of the ...
Yucel N +4 more
europepmc +2 more sources
Moderate exercise improves function and increases adiponectin in the mdx mouse model of muscular dystrophy. [PDF]
Sci Rep, 2019 The loss of dystrophin produces a mechanically fragile sarcolemma, causing muscle membrane disruption and muscle loss. The degree to which exercise alters muscular dystrophy has been evaluated in humans with Duchenne Muscular Dystrophy (DMD) and in mouse
Zelikovich AS +4 more
europepmc +2 more sources
Chronic N‐acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy [PDF]
Experimental PhysiologyDuchenne muscular dystrophy (DMD) is characterised by respiratory muscle injury, inflammation, fibrosis and weakness, ultimately culminating in respiratory failure.
Michael N. Maxwell +5 more
doaj +2 more sources
Eosinophils Do Not Drive Acute Muscle Pathology in the mdx Mouse Model of Duchenne Muscular Dystrophy. [PDF]
J Immunol, 2019 Key Points Eosinophils are prominent in quadriceps lesions of dystrophin-deficient mdx mice. Muscle damage was evaluated quantitatively in mdx, mdx.PHIL, and mdx.IL5tg mice.
Sek AC +8 more
europepmc +2 more sources
The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse. [PDF]
Sci Rep, 2019 The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis.
Bahri OA +5 more
europepmc +2 more sources
Integrative effects of dystrophin loss on metabolic function of the mdx mouse. [PDF]
Sci Rep, 2018 Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin.
Strakova J +7 more
europepmc +2 more sources