Results 21 to 30 of about 1,087,549 (254)
IL-6 signaling blockade increases inflammation but does not affect muscle function in the
BMC Musculoskeletal Disorders, 2012 Background IL-6 is a pleiotropic cytokine that modulates inflammatory responses and plays critical roles in muscle maintenance and remodeling. In the mouse model (mdx) of Duchenne Muscular Dystrophy, IL-6 and muscle inflammation are elevated, which is ...
Kostek Matthew C +6 more
doaj +2 more sources
Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse Model and Patients [PDF]
Frontiers in Physiology, 2021 Duchenne muscular dystrophy (DMD) is a rare genetic disease due to dystrophin gene mutations which cause progressive weakness and muscle wasting. Circadian rhythm coordinates biological processes with the 24-h cycle and it plays a key role in maintaining
Rachele Rossi +21 more
doaj +2 more sources
Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia [PDF]
Skeletal Muscle, 2015 Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits our ability to evaluate the effectiveness
William Duddy +9 more
openalex +2 more sources
Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response. [PDF]
FEBS JDuchenne muscular dystrophy is a severe neuromuscular wasting disease that is caused by a primary defect in dystrophin protein. A targeted mass‐spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy.
Johnson EE, Ervasti JM.
europepmc +2 more sources
iScience, 2022 Summary: The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in ...
Riley E.G. Cleverdon +8 more
doaj +1 more source
Human Gene Therapy, 2021 Duchenne muscular dystrophy (DMD) is a rare, X-linked, fatal, degenerative neuromuscular disease caused by mutations in the DMD gene. More than 2,000 mutations of the DMD gene are responsible for progressive loss of muscle strength, loss of ambulation ...
R. Potter +6 more
semanticscholar +1 more source
Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. [PDF]
PLoS ONE, 2015 Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (DMD), but none of these approaches have led to significant long-term effects in patients.
Kelly M Gutpell +2 more
doaj +1 more source
Plantarflexion Contracture in the mdx Mouse [PDF]
American Journal of Physical Medicine & Rehabilitation, 2010 Contractures are a major clinical issue for patients with muscular dystrophies. However, it is unknown whether contractures are present in the widely used mdx mouse model of Duchenne muscular dystrophy. Therefore, the objectives of this study were to develop methods to measure muscle contractures in mice, to determine whether plantarflexion ...
Lisa L. Dorsey +4 more
openaire +3 more sources
Frontiers in Behavioral Neuroscience, 2021 Duchenne muscular dystrophy (DMD) is a severe, progressive neuromuscular disorder caused by mutations in the DMD gene resulting in loss of functional dystrophin protein.
S. Engelbeen +4 more
semanticscholar +1 more source
T-Cell-Dependent Fibrosis in the mdx Dystrophic Mouse [PDF]
Laboratory Investigation, 2000 In Duchenne muscular dystrophy patients, the pathological hallmark of the disease, namely, the chronic accumulation of sclerotic scar tissue in the interstitial space of skeletal muscle is attributed to manifestation of secondary pathological processes.
Morrison, J +4 more
openaire +3 more sources