Results 21 to 30 of about 9,256 (223)
Cognitive impairment appears progressive in the mdx mouse. [PDF]
Neuromuscul Disord, 2020 Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease caused by mutations in the DMD gene, which encodes the large cytoskeletal protein dystrophin. Approximately one-third of DMD patient's exhibit cognitive problems yet it is unknown if cognitive impairments worsen with age.
Bagdatlioglu E +4 more
europepmc +4 more sources
Plantarflexion Contracture in the mdx Mouse [PDF]
American Journal of Physical Medicine & Rehabilitation, 2010 Contractures are a major clinical issue for patients with muscular dystrophies. However, it is unknown whether contractures are present in the widely used mdx mouse model of Duchenne muscular dystrophy. Therefore, the objectives of this study were to develop methods to measure muscle contractures in mice, to determine whether plantarflexion ...
Michael W, Garlich +4 more
openaire +2 more sources
Increased caveolin‐3 levels in mdx mouse muscles [PDF]
FEBS Letters, 1998 The density of skeletal muscle caveolae is increased in Duchenne muscular dystrophy and its genetic homologue, the mdx mouse. This structural change is significant as it may indicate muscle regeneration. We identified in mdx mouse tibialis anterior muscles significantly increased levels of caveolin‐3, the chief protein in muscle caveolae, and reduced ...
Vaghy, Pal L. +3 more
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Data in Brief, 2018 Here we present original data related to the research paper entitled “Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of Key Metabolic and Contractile Proteins after chronic exercise and the potential modulation by anti ...
Tania Gamberi +8 more
doaj +1 more source
Sports, 2018 An increasing number of studies have shown supplementation with the amino acid taurine to have promise in ameliorating dystrophic symptoms in the mdx mouse model of Duchenne Muscular Dystrophy (DMD).
Robert G. Barker +3 more
doaj +1 more source
Social stress is lethal in the mdx model of Duchenne muscular dystrophy
EBioMedicine, 2020 Background: Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching the ...
Maria Razzoli +10 more
doaj +1 more source
Neurobiology of Disease, 2002 The nicotinic acetylcholine receptor (nAChR) subtypes were characterized in the superior cervical ganglion (SCG) of wild-type and dystrophin-lacking mdx mice.
Arianna Del Signore +4 more
doaj +1 more source
Caspase-12 ablation preserves muscle function in the mdx mouse [PDF]
Human Molecular Genetics, 2014 Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by mutations in dystrophin. Several downstream consequences of dystrophin deficiency are triggers of endoplasmic reticulum (ER) stress, including loss of calcium homeostasis, hypoxia and oxidative stress.
Catherine Moorwood, Elisabeth R. Barton
openalex +3 more sources
Data in Brief, 2018 The data contain body weights, plasma free fatty acids concentrations and cardiac uncoupling protein-3 protein levels for wild-type and mdx mice. The data provide heart rates, left ventricular contractile functions, coronary flow, phosphocreatine ...
Wen Zhang +4 more
doaj +1 more source
Disease Models & Mechanisms, 2014 Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles.
Chunhui Jiang +5 more
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