Results 31 to 40 of about 1,087,549 (254)

Quantitative T2 combined with texture analysis of nuclear magnetic resonance images identify different degrees of muscle involvement in three mouse models of muscle dystrophy: mdx, Largemyd and mdx/Largemyd.

PLoS ONE, 2015
Quantitative nuclear magnetic resonance imaging (MRI) has been considered a promising non-invasive tool for monitoring therapeutic essays in small size mouse models of muscular dystrophies.
Aurea B Martins-Bach, Jackeline Malheiros, Béatrice Matot, Poliana C M Martins, Camila F Almeida, Waldir Caldeira, Alberto F Ribeiro, Paulo Loureiro de Sousa, Noura Azzabou, Alberto Tannús, Pierre G Carlier, Mariz Vainzof   +11 more
doaj   +1 more source

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in themdxmouse [PDF]

Human Molecular Genetics, 2015
Caroline Godfrey, S. Muses, Graham McClorey, Kim E. Wells, Thibault Coursindel, Rebecca Terry, Corinne Betts, Suzan M. Hammond, Liz O’Donovan, John Hildyard, Samir EL Andaloussi, Michael J. Gait, Matthew J. A. Wood, Dominic J. Wells   +13 more
openalex   +2 more sources

Wild-type mouse models to screen antisense oligonucleotides for exon-skipping efficacy in Duchenne muscular dystrophy. [PDF]

PLoS ONE, 2014
A readily available animal model is essential for rapidly identifying effective treatments for Duchenne muscular dystrophy (DMD), a devastating neuromuscular disorder caused by the lack of dystrophin protein, which results from frame-disrupting mutations
Limin Cao, Gang Han, Ben Gu, HaiFang Yin
doaj   +1 more source

Hematopoietic Prostaglandin D Synthase Inhibitor PK007 Decreases Muscle Necrosis in DMD mdx Model Mice

Life, 2021
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and wasting due to the lack of dystrophin protein. The acute phase of DMD is characterized by muscle necrosis and increased levels of the pro-inflammatory mediator ...
Sai Yarlagadda, Christina Kulis, Peter G. Noakes, Mark L. Smythe   +3 more
doaj   +1 more source

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse [PDF]

Human Molecular Genetics, 2012
Loss of dystrophin protein due to mutations in the DMD gene causes Duchenne muscular dystrophy. Dystrophin loss also leads to the loss of the dystrophin glycoprotein complex (DGC) from the sarcolemma which contributes to the dystrophic phenotype.
Gaynor Miller, Chris Moore, Rebecca Terry, Tracy La Riviere, Andrew J. Mitchell, Robert W. Piggott, T. Neil Dear, Dominic J. Wells, Steve J. Winder   +8 more
openalex   +6 more sources

Comparative study of mesenchymal stem cells from C57BL/10 and mdx mice

BMC Cell Biology, 2008
Background Human mesenchymal stem cells (MSCs) have been studied and applied extensively because of their ability to self-renew and differentiate into various cell types. Since most human diseases models are murine, mouse MSCs should have been studied in
Xu Yong-feng, Zhao Cui-ping, Shang Yan-chang, Peng Fu-lin, Yu Mei-juan, Xiong Fu, Zhang Cheng, Li Yong, Liu Zheng-shan, Zhou Chang, Wu Jin-lang   +10 more
doaj   +1 more source

A reporter mouse for optical imaging of inflammation in mdx muscles [PDF]

Skeletal Muscle, 2015
Duchenne muscular dystrophy (DMD) is due to mutations in the gene coding for human DMD; DMD is characterized by progressive muscle degeneration, inflammation, fat accumulation, and fibrosis. The mdx mouse model of DMD lacks dystrophin protein and undergoes a predictable disease course.
Martinez, Leonel, Ermolova, Natalia V, Ishikawa, Tomo-O, Stout, David B, Herschman, Harvey R, Spencer, Melissa J   +5 more
openaire   +5 more sources

Long-term Exon Skipping Studies With 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models

Molecular Therapy: Nucleic Acids, 2012
Antisense-mediated exon skipping for Duchenne muscular dystrophy (DMD) is currently tested in phase 3 clinical trials. The aim of this approach is to modulate splicing by skipping a specific exon to reframe disrupted dystrophin transcripts, allowing the ...
Christa L Tanganyika-de Winter, Hans Heemskerk, Tatyana G Karnaoukh, Maaike van Putten, Sjef J de Kimpe, Judith van Deutekom, Annemieke Aartsma-Rus   +6 more
doaj   +1 more source

Evaluation of Cardiac Function in Young Mdx Mice Using MRI with Feature Tracking and Self-Gated Magnetic Resonance Cine Imaging

Diagnostics, 2023
This study aimed to evaluate cardiac function in a young mouse model of Duchenne muscular dystrophy (mdx) using cardiac magnetic resonance imaging (MRI) with feature tracking and self-gated magnetic resonance cine imaging.
Junpei Ueda, Shigeyoshi Saito
doaj   +1 more source

Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse

Journal of Physiology, 2020
Desmin, similar to dystrophin, is associated with costameric structures bridging sarcomeres to the extracellular matrix. Deletion of the desmin gene in mdx mice [double knockout (DKO) mice] induces marked muscle weakness and fatigue resistance compared ...
A. Ferry, J. Messéant, A. Parlakian, M. Lemaître, Pauline Roy, C. Delacroix, A. Lilienbaum, Yeranuhi Hovhannisyan, D. Furling, A. Klein, Zhenlin Li, O. Agbulut   +11 more
semanticscholar   +1 more source