Results 41 to 50 of about 1,087,549 (254)
Temporal changes in magnetic resonance imaging in the mdx mouse [PDF]
BMC Research Notes, 2013 Abstract Background Duchenne muscular dystrophy (DMD) is characterized clinically by severe, progressive loss of skeletal muscle. The phenotype is much less severe in the mdx mouse model of DMD than that seen in patients with DMD. However, a “critical period” has been described for the mdx mouse, during which there is
Su Xu +3 more
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Data in Brief, 2018 Here we present original data related to the research paper entitled “Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of Key Metabolic and Contractile Proteins after chronic exercise and the potential modulation by anti ...
Tania Gamberi +8 more
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Decrease in Prosaposin in the Dystrophic mdx Mouse Brain
PLoS ONE, 2013 Duchenne muscular dystrophy caused by a mutation in the X-linked dystrophin gene induces metabolic and structural disorders in the brain. A lack of dystrophin in brain structures is involved in impaired cognitive function. Prosaposin (PS), a neurotrophic factor, is abundant in the choroid plexus and various brain regions.
Hui Ling Gao +8 more
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Sports, 2018 An increasing number of studies have shown supplementation with the amino acid taurine to have promise in ameliorating dystrophic symptoms in the mdx mouse model of Duchenne Muscular Dystrophy (DMD).
Robert G. Barker +3 more
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Social stress is lethal in the mdx model of Duchenne muscular dystrophy
EBioMedicine, 2020 Background: Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching the ...
Maria Razzoli +10 more
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Assessing Functional Performance in the <em>Mdx</em> Mouse Model [PDF]
Journal of Visualized Experiments, 2014 Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder for which no cure is available. Nevertheless, several potential pharmaceutical compounds and gene therapy approaches have progressed into clinical trials. With improvement in muscle function being the most important end point in these trials, a lot of emphasis has ...
Annemieke Aartsma‐Rus +1 more
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Increased caveolin‐3 levels in mdx mouse muscles [PDF]
FEBS Letters, 1998 The density of skeletal muscle caveolae is increased in Duchenne muscular dystrophy and its genetic homologue, the mdx mouse. This structural change is significant as it may indicate muscle regeneration. We identified in mdx mouse tibialis anterior muscles significantly increased levels of caveolin‐3, the chief protein in muscle caveolae, and reduced ...
Wenrong Wu +3 more
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Neurobiology of Disease, 2002 The nicotinic acetylcholine receptor (nAChR) subtypes were characterized in the superior cervical ganglion (SCG) of wild-type and dystrophin-lacking mdx mice.
Arianna Del Signore +4 more
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Data in Brief, 2018 The data contain body weights, plasma free fatty acids concentrations and cardiac uncoupling protein-3 protein levels for wild-type and mdx mice. The data provide heart rates, left ventricular contractile functions, coronary flow, phosphocreatine ...
Wen Zhang +4 more
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Cardiomyocyte Regeneration in the mdx Mouse Model of Nonischemic Cardiomyopathy [PDF]
Stem Cells and Development, 2015 Endogenous regeneration has been demonstrated in the mammalian heart after ischemic injury. However, approximately one-third of cases of heart failure are secondary to nonischemic heart disease and cardiac regeneration in these cases remains relatively unexplored.
WA Owens +3 more
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