Results 51 to 60 of about 1,087,549 (254)
Disease Models & Mechanisms, 2014 Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles.
Chunhui Jiang +5 more
doaj +1 more source
rAAVrh74.MCK.GALGT2 Protects against Loss of Hemodynamic Function in the Aging mdx Mouse Heart. [PDF]
Mol Ther, 2019 Xu R, Jia Y, Zygmunt DA, Martin PT.
europepmc +2 more sources
Aquaporin 4 Expression in the mdx Mouse Diaphragm
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2011 Expression of aquaporin (AQP) 4 in the surface membranes of skeletal myofibers is well established; however, its functional significance is still unknown. The alterations of AQP4 expressions in dystrophic muscles at RNA and protein levels have been reported in various dystrophic muscles such as dystrophinopathy, dysferlinopathy, and sarcoglycanopathy ...
Takahiro Jimi +6 more
openaire +4 more sources
Natural disease history of the D2-mdx mouse model for Duchenne muscular dystrophy
The FASEB Journal, 2019 The C57BL/10ScSn‐Dmdmdx/J (BL10‐mdx) mouse has been the most commonly used model for Duchenne muscular dystrophy (DMD) for decades. Their muscle dysfunction and pathology is, however, less severe than in patients with DMD, which complicates preclinical ...
M. van Putten +6 more
semanticscholar +1 more source
Molecular and genetic mapping of the mouse mdx locus
Genomics, 1988 mdx is an X-linked muscular dystrophy mutant of the mouse and a putative homolog of the human X-linked muscular dystrophy locus--Duchenne muscular dystrophy (DMD). Utilizing a C57BL/10/Mus Spretus interspecific cross in which the mdx mutation was segregating, we have constructed a detailed genetic map around the mdx locus on the mouse X chromosome.
Stephen D.M. Brown +6 more
openaire +2 more sources
JACC: Basic to Translational Science, 2016 Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated.
Kurt W. Prins, MD, PhD +4 more
doaj +1 more source
Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice. [PDF]
PLoS ONE, 2011 Duchenne muscular dystrophy (DMD) is an incurable degenerative muscle disorder. We injected WT mouse induced pluripotent stem cells (iPSCs) into mdx and mdx∶utrophin mutant blastocysts, which are predisposed to develop DMD with an increasing degree of ...
Amanda J Beck +9 more
doaj +1 more source
Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle
Frontiers in Physiology, 2022 In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin and
William J. Valentine +15 more
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Molecular Therapy: Methods & Clinical Development, 2019 Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the dystrophin gene that result in the complete absence of dystrophin protein.
Ryan D. Wuebbles +6 more
doaj +1 more source
Animal Models and Experimental Medicine, 2022 The mdx mouse is a model of Duchenne muscular dystrophy (DMD), a fatal progressive muscle wasting disease caused by dystrophin deficiency, and is used most widely in preclinical studies.
Taku Shirakawa +10 more
doaj +1 more source