Results 61 to 70 of about 1,087,549 (254)
Marginal level dystrophin expression improves clinical outcome in a strain of dystrophin/utrophin double knockout mice. [PDF]
PLoS ONE, 2010 Inactivation of all utrophin isoforms in dystrophin-deficient mdx mice results in a strain of utrophin knockout mdx (uko/mdx) mice. Uko/mdx mice display severe clinical symptoms and die prematurely as in Duchenne muscular dystrophy (DMD) patients.
Dejia Li, Yongping Yue, Dongsheng Duan
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PLoS ONE, 2019 The mdx mouse is the most widely-used animal model of the human disease Duchenne muscular dystrophy, and quantitative PCR analysis of gene expression in the muscles of this animal plays a key role in the study of pathogenesis and disease progression and ...
J. Hildyard, Amber M Finch, D. Wells
semanticscholar +1 more source
Effects of T-Lymphocyte Depletion on Muscle Fibrosis in the mdx Mouse [PDF]
The American Journal of Pathology, 2005 Duchenne muscular dystrophy was initially described as a myosclerosis because of the conspicuous progression of interstitial fibrosis. Using the mdx mouse homologue, we have shown previously that the accumulation of intramuscular collagen is profoundly influenced by the presence or absence of T lymphocytes.
Morrison, J +4 more
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Toxicology Reports, 2015 Phosphorodiamidate morpholino oligonucleotides (PMO) are used as a promising exon-skipping gene therapy for Duchenne muscular dystrophy (DMD). One potential complication of high dose PMO therapy is its transient accumulation in the kidneys. Therefore new
Aiping Zhang +10 more
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Disease Models & Mechanisms, 2020 The muscular dystrophy X-linked (mdx) mouse is commonly used as a mouse model of Duchenne muscular dystrophy (DMD). Its phenotype is, however, mild, and other mouse models have been explored.
Claire L. Wood +11 more
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X chromosome-linked muscular dystrophy (mdx) in the mouse. [PDF]
Proceedings of the National Academy of Sciences, 1984 An X chromosome-linked mouse mutant (gene symbol, mdx) has been found that has elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits histological lesions characteristic of muscular dystrophy. The mutants show mild clinical symptoms and are viable and fertile.
Bulfield, G +3 more
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Exosome-Mediated Benefits of Cell Therapy in Mouse and Human Models of Duchenne Muscular Dystrophy
Stem Cell Reports, 2018 Summary: Genetic deficiency of dystrophin leads to disability and premature death in Duchenne muscular dystrophy (DMD), affecting the heart as well as skeletal muscle.
Mark A. Aminzadeh +15 more
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Neuronal Intracellular Ca2+ and Na+ Dyshomeostasis in the MDX Mouse [PDF]
Biophysical Journal, 2016 Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder characterized by the deficiency of dystrophin as well as intracellular ion (Ca2+ and Na+) dyshomeostasis in skeletal and cardiac muscles. There is also an absence of dystrophin in cortical neurons of DMD patients and animal models. We hypothesized that similar to muscles, intracellular
Jose R. Lopez +2 more
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Localization of the mdx mutation within the mouse dystrophin gene. [PDF]
The EMBO Journal, 1988 We have mapped human and mouse X chromosome-specific genomic and cDNA probes through an interspecies Mus musculus/spretus pedigree which contains the mdx mutation. The positions of these markers relative to one another and to the mdx mutation were delineated.
Mark G. Darlison +7 more
openaire +3 more sources
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source