Results 71 to 80 of about 9,256 (223)

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

A reporter mouse for optical imaging of inflammation in mdx muscles [PDF]

Skeletal Muscle, 2015
Duchenne muscular dystrophy (DMD) is due to mutations in the gene coding for human DMD; DMD is characterized by progressive muscle degeneration, inflammation, fat accumulation, and fibrosis. The mdx mouse model of DMD lacks dystrophin protein and undergoes a predictable disease course.
Martinez, Leonel, Ermolova, Natalia V, Ishikawa, Tomo-O, Stout, David B, Herschman, Harvey R, Spencer, Melissa J   +5 more
openaire   +4 more sources

Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
We sought to determine a causal role for the microbiota in promoting dystrophic muscle characteristics by performing intra/inter‐genotype fecal microbiota transplantations (FMT) between wildtype (C57BL/10) and mdx (C57BL/10ScSn‐Dmdmdx/J) mice. We found that transplantation of mdx microbiotas into a wildtype mouse induced an mdx‐like muscle phenotype ...
James Butcher, Jessica T. Gosse, Jonathan Gobin, Aymeric Ravel‐Chapuis, Bernard J. Jasmin, Alain Stintzi   +5 more
wiley   +1 more source

Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging

Journal of Cardiovascular Magnetic Resonance, 2009
Background Duchenne muscular dystrophy (DMD) is caused by the absence of the cytoskeletal protein, dystrophin. In DMD patients, dilated cardiomyopathy leading to heart failure may occur during adolescence. However, early cardiac dysfunction is frequently
Zhong Jia, Liu Wei, Li Wei, Yu Xin
doaj   +1 more source

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation

European Journal of Immunology, Volume 55, Issue 12, December 2025.
This review summarizes emerging spatially resolved multi‐omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche‐specific immunopathology that shape cellular reactivity and vulnerability.
Thorge Dobbertin, Lucas Schirmer
wiley   +1 more source

Misplaced Golgi Elements Produce Randomly Oriented Microtubules and Aberrant Cortical Arrays of Microtubules in Dystrophic Skeletal Muscle Fibers

Frontiers in Cell and Developmental Biology, 2019
Differentiated mammalian cells and tissues, such as skeletal muscle fibers, acquire an organization of Golgi complex and microtubules profoundly different from that in proliferating cells and still poorly understood.
Sarah Oddoux, Davide Randazzo, Aster Kenea, Bruno Alonso, Kristien J. M. Zaal, Evelyn Ralston   +5 more
doaj   +1 more source

Dose‐ and Duration‐Dependent Effects of Propylene Glycol on Lipid Metabolism‐Related mRNAs, Proteins, and Fatty Acids in the Adipose Tissue of Fattening Akkaraman Lambs

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Propylene glycol modulated lipid metabolism in gluteal fat tissue. Expression of FABP4 at Day 60 and 120, and PPARγ and C/EBPα at Day 120 were upregulated, while SREBP1c was downregulated at both the mRNA (Day 120) and protein levels (Day 60 and 120).
Akın Yakan, Hüseyin Özkan, Hasan Hüseyin Keçeli, Ufuk Kaya, Irem Karaaslan, Sevda Dalkiran, Necmettin Ünal, Baran Çamdeviren, Güven Güngör, Mehmet Küçükoflaz, Savaş Sariözkan, Korhan Arslan, Bilal Akyüz, Aytaç Akçay, Ceyhan Özbeyaz   +14 more
wiley   +1 more source

Fast Myosin Binding Protein‐C Is a Vital Regulator in Young and Aged Fast Skeletal Muscle Homeostasis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast‐twitch muscle fibres are characterized by their rapid contraction kinetics, high‐force generation and a distinct gene expression profile compared to slow‐twitch fibres.
Akhil Baby, Kalyani Ananthamohan, Brenna N. McIntyre, Sankar Natesan, Taejeong Song   +4 more
wiley   +1 more source

Exploring Desmin as a Potential Modifier in Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Duchenne muscular dystrophy (DMD), a rare X‐linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is altered in DMD patients, may influence disease progression.
Brice‐Emmanuel Guennec, Yeranuhi Hovhannisyan, Gaëlle Revet, Sila Polat, Medhi Hassani, Nathalie Mougenot, Inès Barthelemy, Stephane Blot, Caroline Cieniewski‐Bernard, Arnaud Ferry, Ekaterini Kordeli, Zhenlin Li, Onnik Agbulut   +12 more
wiley   +1 more source

Components of the NGF signaling complex are altered in mdx mouse superior cervical ganglion and its target organs

Neurobiology of Disease, 2008
We previously reported that in the superior cervical ganglion (SCG) of dystrophic mdx mice, which lack full-length dystrophin, there is a loss of neurons projecting to SCG muscular targets, like the iris.
Loredana Lombardi, M. Egle De Stefano, Paola Paggi   +2 more
doaj   +1 more source