Visual Discrimination, Serial Reversal, and Extinction Learning in the mdx Mouse
Frontiers in Behavioral Neuroscience, 2019 Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy and the most common neuromuscular disorder. In addition to neuromuscular consequences, some individuals with DMD experience global intellectual dysfunction and executive ...
Price E. Dickson, Guy Mittleman
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Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) [PDF]
, 2012 BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available.
Lin, Shuo +2 more
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Sharing the load: compensatory pressure generation in the mdx mouse model. [PDF]
J Physiol, 2019 Khurram OU.
europepmc +3 more sources
Combating muscle atrophy: emerging therapeutic targets that are fiber‐type‐specific
The FEBS Journal, EarlyView.Inflammation, denervation or decreased insulin signaling activate proteolysis and cause muscle wasting. Pathological conditions like obesity and DMD can also exacerbate atrophy via PGD2–RhoA–ROCK2 signaling. In contrast, exercise, dietary interventions, and pharmacological agents can activate Ca2+/calcineurin–NFAT and AMPK–PGC‐1α–MEF pathways ...
Samrat Chakraborty +2 more
wiley +1 more source
Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway [PDF]
, 2015 Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation.
Petrillo, Sara +10 more
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Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice. [PDF]
PLoS ONE, 2018 The lack of dystrophin in Duchenne muscular dystrophy (DMD) compromises the integrity and function of muscle fibers. Skeletal muscles, except the diaphragm, do not undergo progressive degeneration in adult mdx mice due to compensatory mechanisms ...
Antoine Boulanger Piette +7 more
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Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy [PDF]
Journal of Anatomy, 2016 Isabel Cristina Chagas Barbin +5 more
semanticscholar +2 more sources
Clinical application of additive manufacturing in maxillofacial prosthetics: A scoping review
Journal of Prosthodontics, EarlyView.Abstract Purpose Digital workflows provide significant advances in prosthodontics, especially in terms of accuracy, reduced treatment duration, and quality of life. Moreover, additive manufacturing (AM) is particularly adapted for the fabrication of personalized complex prototypes required for the prosthetic rehabilitation of maxillofacial defects ...
Hélène Magro +2 more
wiley +1 more source
Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis
Scientific Reports, 2017 Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn −/− mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of
Hung-Chih Chen +6 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane‐prostanoid receptor (TPr) increases calcium transients in cardiomyocytes ...
James D. West +10 more
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