Results 51 to 60 of about 309,715 (264)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Convergence and MS Stability of Exponential Euler Method for Semilinear Stochastic Differential Equations

Abstract and Applied Analysis, 2012
The numerical approximation of exponential Euler method is constructed for semilinear stochastic differential equations (SDEs). The convergence and mean-square (MS) stability of exponential Euler method are investigated. It is proved that the exponential
Chunmei Shi, Yu Xiao, Chiping Zhang
doaj   +1 more source

Design of Event-Triggered Fault-Tolerant Control for Stochastic Systems with Time-Delays

Sensors, 2018
This paper proposes two novel, event-triggered fault-tolerant control strategies for a class of stochastic systems with state delays. The plant is disturbed by a Gaussian process, actuator faults, and unknown disturbances.
Yi Gao, YunJi Li, Li Peng, Junyu Liu
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Stability of Stochastic Delayed Recurrent Neural Networks

Mathematics
This paper addresses the stability of stochastic delayed recurrent neural networks (SDRNNs), identifying challenges in existing scalar methods, which suffer from strong assumptions and limited applicability.
Hongying Xiao, Mingming Xu, Yuanyuan Zhang, Shengquan Weng   +3 more
doaj   +1 more source

Stability of Analytical and Numerical Solutions for Nonlinear Stochastic Delay Differential Equations with Jumps

Abstract and Applied Analysis, 2012
This paper is concerned with the stability of analytical and numerical solutions for nonlinear stochastic delay differential equations (SDDEs) with jumps. A sufficient condition for mean-square exponential stability of the exact solution is derived. Then,
Qiyong Li, Siqing Gan
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mean-square exponential input-to-state stability of stochastic quaternion-valued neural networks with time-varying delays

Advances in Difference Equations, 2021
In this paper, we first consider the stability problem for a class of stochastic quaternion-valued neural networks with time-varying delays. Next, we cannot explicitly decompose the quaternion-valued systems into equivalent real-valued systems; by using ...
Lihua Dai, Yuanyuan Hou
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Analysis of stability for stochastic delay integro-differential equations

Journal of Inequalities and Applications, 2018
In this paper, we concern stability of numerical methods applied to stochastic delay integro-differential equations. For linear stochastic delay integro-differential equations, it is shown that the mean-square stability is derived by the split-step ...
Yu Zhang, Longsuo Li
doaj   +1 more source