Results 161 to 170 of about 9,082,759 (197)
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.Aluminum‐enhanced afterburning renders AE explosives more hazardous than conventional ones. Corrugated steel linings reduce far‐field AE blast overpressure by ~50% through wave reflection and dissipation. The developed model accurately predicts peak pressure (<10% error) and arrival time (<3% error), supporting protective design.
Zhen Wang +5 more
wiley +1 more source
Investigation on tunnel stability considering pipe‐roof support with transparent soil technology
Deep Underground Science and Engineering, EarlyView.This study integrates transparent soil technology, 3D reconstruction and numerical simulation to captures the full‐field deformation of shield tunnel instability. Results demonstrate that pipe‐roof support enhances stability via the “soil‐arching barrier effect,” effectively restraining failure wedge development by extending stress transfer paths ...
Zhi Jia +4 more
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.The graphical abstract illustrates a reconstructed in situ thermo‐hydro‐mechanical (THM) framework in which porosity serves as the central variable linking stress, pore pressure, and temperature to evolving mechanical properties of rocks. Under burial conditions, in situ stress, pore pressure, and temperature jointly govern volumetric strain and ...
Mingyuan Lu +5 more
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.This study proposes an eco‐friendly coal permeability enhancement technique by utilizing mine waste gangue as an abrasive in high‐pressure water jets. Integrating erosion experiments with smoothed particle hydrodynamics‐finite element method coupled simulations, the research study elucidates the flow field dynamics and a nonlinear solid–liquid ...
Qingxiang Wang +4 more
wiley +1 more source
Modeling proppant transport and settling in a 3D propagating fracture
Deep Underground Science and Engineering, EarlyView.A versatile multiphysics tool is presented for simulating the complex processes involved in hydraulic fracturing treatments. The model couples fracture opening and propagation, variable‐density slurry flow, and proppant particle transport within the multiphysics object‐oriented simulation environment framework, based on two‐phase mixture equations and ...
Robert Egert +2 more
wiley +1 more source
Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges
Epilepsia Open, EarlyView.Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus +7 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract EEG‐based connectivity analysis has emerged as a promising approach for investigating brain network dynamics in clinical epilepsy research. However, the diversity of analytical approaches, preprocessing pipelines, and reporting practices poses challenges to reproducibility and clinical translation.
Naoto Kuroda +6 more
wiley +1 more source
Complex Versus Parsimonious Site‐Based Stochastic Ground Motion Models: Which One Is Better?
Earthquake Engineering &Structural Dynamics, EarlyView.ABSTRACT Stochastic ground motion models (GMMs) provide a probabilistic representation of seismic input and are increasingly important for uncertainty quantification (UQ) in earthquake engineering. This study focuses on site‐based stochastic GMMs, which learn the statistical features of selected datasets of seismic records and generate statistically ...
Maijia Su +2 more
wiley +1 more source