Results 191 to 200 of about 6,923,144 (262)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pronounced Neuroplasticity in the Primary Visual Cortex of the 13-Lined Ground Squirrel during Hibernation. [PDF]

J Neurosci
Fultz A, Mejias-Aponte CA, Jacob C, Castillo L, Nadal-Nicolas FM, Gao Y, Li W, Nienborg H.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders. [PDF]

Psychol Med
Selitser M, McWhinney SR, Wu L, Fraiha-Pegado J, Dietze L, Corkum E, Selitser L, Nunes A, Alda M, Franke K, Hajek T.   +10 more
europepmc   +1 more source

Interpretable Machine Learning for Predicting Metabolic Syndrome-Kidney Stone Disease Comorbidity: The Role of Dietary Micronutrients. [PDF]

Food Sci Nutr
Wu G, Qin H, Yao J, Liu Y, Zheng J, Wang J, Hao Z, Tao L.   +7 more
europepmc   +1 more source

Neuro-behavioral Impact of Tourette-Related Striatal Disinhibition in Rats. [PDF]

eNeuro
Loayza J, Taylor CJL, Renstrom JG, Grasmeder Allen R, Jackson SR, Bast T.   +5 more
europepmc   +1 more source

Predictive Modeling of Enterovirus Hospital Burden Using Machine Learning and Age-Specific Surveillance Data: Operational Forecasting in Taiwan During the Postpandemic Era. [PDF]

JMIR Form Res
Kuan MM.
europepmc   +1 more source

AI-Assisted UBM versus Conventional Sizing Approaches for ICL Implantation: A Retrospective Analysis of Vault Outcomes. [PDF]

Clin Ophthalmol
Ang RET, Glipo CER, Martinez GHA, Yutangco RJM, Cruz EM.   +4 more
europepmc   +1 more source