Results 271 to 280 of about 333,354 (320)

Rituximab and Intravenous Immunoglobulin (IVIG) for Refractory Eosinophilic Fasciitis: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Eosinophilic fasciitis (EF) is a rare condition with an unknown cause. This case study showed that a 40‐year‐old man with EF did not respond to standard treatments but improved after receiving rituximab and intravenous immunoglobulin (IVIG). Further studies are needed to confirm rituximab's effectiveness and long‐term safety for EF.
Maryam Sahebari, Motahhareh Karimoddini, Naser Tayyebi Meibodi, Sajad Ataei Azimi, Shadan Tafreshian   +4 more
wiley   +1 more source

Multi‐Chamber Intracardiac Thrombi Complicated With Pulmonary and Lower Extremity Thrombosis in Male Patient: Case Report and Literature Reviews

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Multi‐chamber intracardiac thrombi are a rare and high‐risk complication in dilated cardiomyopathy, even during sinus rhythm. This case highlights the associated dangers of hemodynamic compromise and systemic embolization. Management requires vigilant anticoagulation and close monitoring to balance thromboembolic and bleeding risks.
Eba Fufa, Yitagesu Getachew, Samson Mulugeta, Abera Birhanu, Abel Yirga, Amdemeskel Mersha, Banchiaymolu Damtie, Balew Arega, Begashaw Belay, Brook Fanuel, Misgana Lukas   +10 more
wiley   +1 more source

When Autoimmunity Meets Malignancy: A Rare Case of Concomitant Systemic Lupus and Multiple Myeloma

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT The association between systemic lupus erythematosus (SLE) and multiple myeloma (MM) is rare, with fewer than 20 cases reported in the literature, raising questions about the link between chronic immune dysregulation and oncogenesis. We report the case of a 43‐year‐old Malagasy woman in whom a monoclonal β2‐globulin spike, incidentally ...
Solohery Jean Noël Ratsimbazafy, Havantsoa Nomena Fandresena Andrianarisambatra, Rajo Païdia Radinasoa, Hitsy Andraina Razafindrazaka, Tahianasoa Randriamampianina, Rija Mikhaël Miandrisoa, Fidiarivony Ralison, Hanta Marie Danielle Vololontiana   +7 more
wiley   +1 more source

First‐In‐Human Study to Assess the Pharmacokinetics and Safety of DS‐6016a After Single Subcutaneous Injection in Healthy Japanese Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Fibrodysplasia ossificans progressiva is a rare, progressive autosomal dominant genetic disease caused by an activin receptor‐like kinase 2 (ALK2) mutation with a need for effective prophylactic therapies. This single‐center, randomized, double‐blind, placebo‐controlled study evaluated the pharmacokinetics and safety of DS‐6016a, a novel ...
Kei Okita, Hidetoshi Furuie, Akifumi Kurata, Yasuko Owada, Satoshi Yoshiba, Kei Furihata, Takaaki Oka, Yushi Kashihara, Hitoshi Ishizuka, Kazutaka Yoshihara   +9 more
wiley   +1 more source

MDS/MPN With SF3B1 Mutation and Thrombocytosis but Without Ring Sideroblasts

American Journal of Hematology, Volume 101, Issue 1, Page 129-130, January 2026.
Biswadip Hazarika, Barbara J. Bain
wiley   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 120-130, January 2026.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

A Randomized, Triple‐Blind, Placebo‐Controlled, Parallel Clinical Trial Investigating Safety and Efficacy of Corn Leaf Extract on Sleep Quality in a Healthy Population With Difficulty Falling or Staying Asleep

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Corn leaf extract (CLE) contains a naturally occurring substance, 6‐methoxybenzoxazolinone (6‐MBOA). Structurally similar to melatonin, 6‐MBOA acts as a weak β‐adrenergic agonist with an affinity for melatonin receptors and stimulating melatonin synthesis.
Katarina M. Doma, Abdelrahman Zamzam, David C. Crowley, Najla Guthrie, Erin D. Lewis   +4 more
wiley   +1 more source

Development of Hyperuricemia and Hyperglycemia After Prolonged Consumption of Clams (Galatea paradoxa) at the Recommended Daily Allowance

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Prolonged consumption of clam, Galatea paradoxa, powder led to dose‐dependent increases in uric acid and blood glucose in rats. Liver weight decreased at the highest dose, accompanied by mild histological alterations. These findings suggest that high clam intake, even within recommended dietary levels, may contribute to metabolic disturbances ...
Samuel Adjei, Matilda Asante, Charles Mills‐Robertson, Samkeliso Takaidza, Vivash Naidoo, Perpetua Dagadu, Stephen Yormasah, Ruth Owu, George A. Asare   +8 more
wiley   +1 more source

Comparative Analysis of the Effects of Mogroside V, Epigallocatechin Gallate, and Resveratrol on Growth Performance, Blood Parameters, Rumen Microbiota, and Short‐Chain Fatty Acid Metabolism in Heat‐Stressed Hu Sheep

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Comparative effects of Mogroside V, EGCG, and resveratrol in heat‐stressed Hu sheep. ABSTRACT Hu sheep are highly prized for their tender meat, but heat stress (HS) caused by the high temperature and humidity in southern China severely impacts their performance.
Yirong Wei, Jun Lu, Shaoqiang Wu, Zhihua Mo, Haien He, Yulong Shen, Jianwei Zou, Cheng Xing, Yanna Huang, Qinyang Jiang   +9 more
wiley   +1 more source