Results 281 to 290 of about 333,354 (320)

MeMAGEN: A Phase IIa/IIb open‐label trial of memantine testing safety and tolerability in sickle cell patients

HemaSphere, Volume 10, Issue 1, January 2026.
ABSTRACT Administration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD). The objectives of the 1‐year dose‐escalation Phase IIa/IIb Memantine trial (MeMAGEN – NCT 03247218) with 17 SCD patients who were under stable ...
Ariel Koren, Carina Levin, Leonid Livshits, Fabio Valeri, Sari Peretz, Sivan Raz, Anna Yu Bogdanova, Max Gassmann   +7 more
wiley   +1 more source

Additive effect of multiple genetic variants in SEC23B and PIEZO1 on iron metabolism dyshomeostasis in hereditary anemias

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Hereditary anemias encompass a genetically heterogeneous spectrum of disorders, often involving multi‐locus inheritance, which can complicate clinical management and worsen disease severity. This study investigates the impact of the co‐inheritance of SEC23B loss‐of‐function pathogenic variants, which lead to congenital dyserythropoietic anemia
Antonella Nostroso, Roberta Marra, Barbara Eleni Rosato, Anthony Iscaro, Federica Maria Esposito, Vanessa D'Onofrio, Manuela Dionisi, Michela Ribersani, Francesca Giordano, Anna Bulla, Giovanni Carlo Del Vecchio, Saverio Scianguetta, Giorgia Mandrile, Teresa Ceglie, Olga Scudiero, Giovanni Battista Ferrero, Silverio Perrotta, Achille Iolascon, Immacolata Andolfo, Roberta Russo   +19 more
wiley   +1 more source

TNFAIP3 Gene Polymorphisms and the Risk of Thrombocytopenia: A Cross‐Sectional Study in Iranian Population

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Thrombocytopenia, particularly immune thrombocytopenic purpura, is a prevalent hematological disorder characterized by low platelet counts, leading to increased bleeding risks. Genetic factors, including single nucleotide polymorphisms, are implicated in its pathogenesis.
Sorour Alizadeh Saadooni, Zeinab Eftekhar, Mohammad Ali Jalali Far, Najmaldin Saki, Gholam Abbas Kydani, Hossein Karimpourian, Ali Aminasnafi   +6 more
wiley   +1 more source

Bayesian Analysis of Frailty Risk Factors in Chronic Kidney Disease: A Nationwide Cross‐Sectional Survey

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Frailty in chronic kidney disease (CKD) patients is associated with increased risk of adverse health outcomes. Understanding the contributing factors to frailty in this population is crucial for developing targeted interventions and improving patient care.
Jiao Wang, Quan Wang, Zian Zhao, Minxin Chen, Dexter Siu‐Hong Wong, James Chung‐Wai Cheung, Duo Wai‐Chi Wong   +6 more
wiley   +1 more source

Feasibility and effectiveness of the novel HemoClear microfiltration cell‐salvage system in cesarean sections in South Africa

International Journal of Gynecology &Obstetrics, Volume 172, Issue 1, Page 396-405, January 2026.
Abstract Objective To test the feasibility and effectiveness of implementing the HemoClear microfiltration cell‐salvage system for cesarean sections in South Africa. Methods We conducted a prospective experimental single‐arm feasibility study collecting and processing blood from 20 adult women undergoing cesarean section in Pelonomi Tertiary Hospital ...
Nndwammbi C. Ramatsea, Marnus Booyens, Joseph B. Sempa, Angélique B. van 't Wout, Edwin Turton, Arno P. Nierich   +5 more
wiley   +1 more source

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Clinical Importance of Mean Corpuscular Volume as a Prognostic Marker After Esophagectomy for Esophageal Cancer: A Retrospective Study.

Annals of Surgery, 2020
OBJECTIVE To elucidate the clinical value of mean corpuscular volume (MCV) for prognostic prediction in patients with esophageal cancer who underwent radical esophagectomy.
N. Yoshida, K. Kosumi, R. Tokunaga, Y. Baba, Y. Nagai, Y. Miyamoto, S. Iwagami, M. Iwatsuki, Y. Hiyoshi, T. Ishimoto, K. Eto, Y. Imamura, Masayuki Watanabe, H. Baba   +13 more
semanticscholar   +1 more source