Results 141 to 150 of about 5,561,344 (365)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Totally real surfaces in CP2 with parallel mean curvature vector

International Journal of Mathematics and Mathematical Sciences, 1992
It has been shown that a totally real surface in CP2 with parallel mean curvature vector and constant Gaussian curvature is either flat or totally geodesic.
M. A. Al-Gwaiz, Sharief Deshmukh
doaj   +1 more source

Local Well-Posedness of Skew Mean Curvature Flow for Small Data in d ≥ 4 Dimensions. [PDF]

Commun Math Phys, 2022
Huang J, Tataru D.
europepmc   +1 more source

Constant mean curvature foliation: singularity structure and curvature estimate [PDF]

Pacific Journal of Mathematics, 1996
The author studies codimension-one foliations of 3-dimensional Riemannian manifolds with leaves of constant mean curvature that can vary from leaf to leaf. The foliations are allowed to have isolated center singularities, that is, points having deleted neighborhoods which are foliated by compact leaves.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Improved Detection of Chronic Obstructive Pulmonary Disease at Chest CT Using the Mean Curvature of Isophotes. [PDF]

Radiol Artif Intell, 2022
Savadjiev P, Gallix B, Rezanejad M, Bhatnagar S, Semionov A, Siddiqi K, Forghani R, Reinhold C, Eidelman DH, Dandurand RJ.   +9 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Differentiating Between Contact Lens Warpage and Keratoconus Using OCT Maps of Corneal Mean Curvature and Epithelial Thickness. [PDF]

J Refract Surg, 2022
Pavlatos E, Harkness B, Louie D, Chamberlain W, Huang D, Li Y.   +5 more
europepmc   +1 more source

Some remarks on Huisken's monotonicity formula for mean curvature flow [PDF]

, 2017
Carlo Mantegazza, Annibale Magni
openalex   +1 more source

Long time behavior of discrete volume preserving mean curvature flows

, 2022
Massimiliano Morini, Marcello Ponsiglione, Emanuele Spadaro   +2 more
openalex   +2 more sources