Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Varifold solutions to volume-preserving mean curvature flow: existence and weak-strong uniqueness. [PDF]
Math AnnPoiatti A.
europepmc +1 more source
On semidiscrete constant mean curvature surfaces and their associated families. [PDF]
Mon Hefte Math, 2017 Carl W.
europepmc +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Pólya-Szegő Inequalities on Submanifolds with Small Total Mean Curvature. [PDF]
J Geom AnalAldrigo P, Balogh ZM.
europepmc +1 more source
Mean curvature and texture constrained composite weighted random walk algorithm for optic disc segmentation towards glaucoma screening. [PDF]
Healthc Technol Lett, 2018 Panda R, Puhan NB, Panda G.
europepmc +1 more source
Surfaces with constant mean curvature
, 2003 The mean curvature of a surface is an extrinsic parameter measuring how the surface is curved in the three-dimensional space. A surface whose mean curvature is zero at each point is a minimal surface, and it is known that such surfaces are models for ...
Kenmotsu, Katsuei
core
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Automated diagnosis of usual interstitial pneumonia on chest CT via the mean curvature of isophotes. [PDF]
Eur J Radiol OpenSavadjiev P +9 more
europepmc +1 more source
Mean Curvature Flow in Euclidean spaces, Lagrangian Mean Curvature Flow, and Conormal Bundles [PDF]
I will present the mean curvature flow in Euclidean spaces and the Lagrangian mean curvature flow. We will first study the mean curvature evolution of submanifolds in Euclidean spaces, with an emphasis on the case of hypersurfaces. Along the way we will
Leung, Chun Ho
core