Results 321 to 330 of about 5,121,571 (362)

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Axial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children. [PDF]

Front Ophthalmol (Lausanne)
Ye Y, Hu Z, Su N, Shen Y, Yuan S.
europepmc   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Corneal Curvature of the Saudi Population in Relation to Age, Gender, Refractive Errors, and Central Corneal Thickness. [PDF]

Cureus
Almazrou AA, Abualnaja A, Abualnaja W, Alqahtani N, Alkhars AZ.   +4 more
europepmc   +1 more source

If it does not help, it might hurt: Pharmacodynamics of a second IVIg course in Guillain–Barré syndrome

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg, Ruth Huizinga, Krista Kuitwaard, Sebastiaan D.T. Sassen, Christa Walgaard, Pieter A. van Doorn, Bart C. Jacobs, Birgit C.P Koch   +7 more
wiley   +1 more source

Fractional CO₂ laser for the treatment of Peyronie's disease A pilot clinical trial. [PDF]

Can Urol Assoc J
Chan JYH, Alhamam A, Witherspoon L, Rivers JK, Flannigan RK.   +4 more
europepmc   +1 more source

Twelve‐month change in quantitative MRI calf muscle fat fraction in CMT1A predicts clinical change over 4 years

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective We measured clinical and quantitative MRI outcome measures in CMT1A to assess long‐term responsiveness, establish longitudinal validity and assess MRI as a bridging biomarker. Methods Twenty patients with CMT1A and 20 matched controls underwent MRI, myometry and clinical assessments up to four times over mean 4‐year follow‐up ...
Matthew R. B. Evans, Hamza A. Salhab, Christopher D. J. Sinclair, Sachit Shah, Michael G. Hanna, Tarek A. Yousry, John S. Thornton, Jasper M. Morrow, Mary M. Reilly   +8 more
wiley   +1 more source

ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas, Changee Han, Woo Jae Kim, Seneshaw Asress, Yingjie Li, Jennifer A. Taylor, Marla Gearing, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass   +10 more
wiley   +1 more source

Counter-Rotate Technique Is Substantial for Correcting Thoracolumbar/Lumbar Curvature in AIS Patients with Thoracic Scoliosis. [PDF]

J Clin Med
Seki S, Newton PO, Makino H, Futakawa H, Kamei K, Yashima Y, Kawaguchi Y.   +6 more
europepmc   +1 more source

Correlations of anterior and posterior corneal parameters in Chinese myopic patients: a retrospective multicenter study. [PDF]

Quant Imaging Med Surg
Hu Y, Wang Y, Du Z, Zhu S, Xiong L, Fang X, Zhou J, Zhang Q, Lei X, Li Y, Zeng J, Wang Z.   +11 more
europepmc   +1 more source