Results 161 to 170 of about 622,007 (303)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

open access: yesFEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia   +5 more
wiley   +1 more source

Investigation of the Uniformity of Gel Shrinkage by Imaging Tracer Particles Using X‐Ray Microtomography

open access: yesAdvanced Engineering Materials, EarlyView., 2023
A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal   +3 more
wiley   +1 more source

Impact of poloidal convective cells on momentum flux in tokamaks

open access: yesNew Journal of Physics, 2017
Radial fluxes of parallel momentum due to $E\times B$ and magnetic drifts are shown to be correlated in tokamak plasmas. This correlation comes from the onset of poloidal convective cells generated by turbulence.
X Garbet   +7 more
doaj   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Planar Waves of the Buffered Bistable System

open access: yesAbstract and Applied Analysis, 2013
This paper is concerned with the large time behavior of disturbed planar fronts in the buffered bistable system in ℝn (n≥2). We first show that the large time behavior of the disturbed fronts can be approximated by that of the mean curvature flow with a
Xiaohuan Wang, Guangying Lv
doaj   +1 more source

Ice flow line maps of three large freshwater calving glaciers in the Southern Patagonian Icefield [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
The Southern Patagonian Icefield is experiencing rapid retreat and thinning in its calving glaciers. To better understand the dynamics of these changes, we generated ice flow line maps for the Viedma, Upsala, and Pio XI glaciers during 2017–2018 ...
E. Lannutti   +12 more
doaj   +1 more source

Soliton solutions for the mean curvature flow [PDF]

open access: bronze, 2000
Norbert Hungerbühler, Knut Smoczyk
openalex   +1 more source

The mean curvature flow by parallel hypersurfaces

open access: yesProceedings of the American Mathematical Society, 2018
It is shown that a hypersurface of a space form is the initial data for a solution to the mean curvature flow by parallel hypersurfaces if, and only if, it is isoparametric. By solving an ordinary differential equation, explicit solutions are given for all isoparametric hypersurfaces of space forms.
Hiuri Fellipe Santos dos Reis   +1 more
openaire   +3 more sources

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