Results 181 to 190 of about 868,975 (356)

The Inverse Mean Curvature Flow and the Riemannian Penrose Inequality [PDF]

, 2001
Gerhard Huisken, Tom Ilmanen
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

General curvature flow without singularities [PDF]

arXiv, 2016
In [5], S\'aez and Schn\"urer studied the graphical mean curvature flow of complete hypersurfaces defined on subsets of Euclidean space. They obtained long time existence. Moreover, they provided a new interpretation of weak mean curvature flow. In this paper, we generalize their results to a general curvature setting.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Computational Flow Diverter Implantation—A Comparative Study on Pre-Interventional Simulation and Post-Interventional Device Positioning for a Novel Blood Flow Modulator

Fluids
Due to their effect on aneurysm hemodynamics, flow diverters (FD) have become a routine endovascular therapy for intracranial aneurysms. Since over- and undersizing affect the device’s hemodynamic abilities, selecting the correct device diameter and ...
Maximilian Thormann, Janneck Stahl, Laurel Marsh, Sylvia Saalfeld, Nele Sillis, Andreas Ding, Anastasios Mpotsaris, Philipp Berg, Daniel Behme   +8 more
doaj   +1 more source

A comparative analysis of the time-dependent magnetized blood-based nanofluids flows over a stretching cylinder

Heliyon, 2023
This article explores the analysis of magnetized blood-based nanofluids flows over an extending cylinder. The nanofluid contains copper, copper oxide and iron oxide nanoparticles which are mixed with blood.
Showkat Ahmad Lone, Sadia Anwar, Anwar Saeed, Thidaporn Seangwattana, Poom Kumam, Wiyada Kumam   +5 more
doaj  

Scalar curvature, isoperimetric collapse and General Relativity in the Constant Mean Curvature gauge [PDF]

arXiv, 2010
We discuss a set of relations, set in the form of results, conjectures and problems, between the L^{2}-norm of the Ricci curvature of a 3-manifold, the scalar curvature and the volume radius. We illustrate the scope of these relations with potential applications to the Einstein Constant Mean Curvature flow (or GR seen as a geometric flow of constant ...
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A comparison principle for singular parabolic equations in the Heisenberg group

Electronic Journal of Differential Equations, 2015
In this work, we prove a comparison principle for singular parabolic equations with boundary conditions in the context of the Heisenberg group. In particular, this result applies to interesting equations, such as the parabolic infinite Laplacian, the
Pablo Ochoa
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source