Results 21 to 30 of about 41,071 (268)

Mean Curvature Type Flow with Perpendicular Neumann Boundary Condition inside a Convex Cone

Abstract and Applied Analysis, 2014
We investigate the evolution of hypersurfaces with perpendicular Neumann boundary condition under mean curvature type flow, where the boundary manifold is a convex cone.
Fangcheng Guo, Guanghan Li, Chuanxi Wu
doaj   +1 more source

Uniqueness of Closed Equilibrium Hypersurfaces for Anisotropic Surface Energy and Application to a Capillary Problem

Mathematical and Computational Applications, 2019
We study a variational problem for hypersurfaces in the Euclidean space with an anisotropic surface energy. An anisotropic surface energy is the integral of an energy density that depends on the surface normal over the considered hypersurface, which was ...
Miyuki Koiso
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Diffuse-interface approximation and weak–strong uniqueness of anisotropic mean curvature flow

European Journal of Applied Mathematics
The purpose of this paper is to derive anisotropic mean curvature flow as the limit of the anisotropic Allen–Cahn equation. We rely on distributional solution concepts for both the diffuse and sharp interface models and prove convergence using relative ...
Tim Laux, Kerrek Stinson, Clemens Ullrich   +2 more
doaj   +1 more source

Combined Effects of Flow Diverting Strategies and Parent Artery Curvature on Aneurysmal Hemodynamics: A CFD Study.

PLoS ONE, 2015
PurposeFlow diverters (FD) are increasingly being considered for treating large or giant wide-neck aneurysms. Clinical outcome is highly variable and depends on the type of aneurysm, the flow diverting device and treatment strategies.
Jinyu Xu, Zhichen Wu, Ying Yu, Nan Lv, Shengzhang Wang, Christof Karmonik, Jian-Min Liu, Qinghai Huang   +7 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Evolution of the first eigenvalue of the Laplace operator and the p-Laplace operator under a forced mean curvature flow

Open Mathematics, 2020
In this paper, we discuss the monotonicity of the first nonzero eigenvalue of the Laplace operator and the p-Laplace operator under a forced mean curvature flow (MCF).
Qi Xuesen, Liu Ximin
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Additive operator splitting scheme for a general mean curvature flow and application in edges enhancement

Journal of Numerical Analysis and Approximation Theory
Many models that use non-linear partial differential equations (PDEs) have been extensively applied for different tasks in image processing. Among these PDE-based approaches, the mean curvature flow filtering has impressive results, for which feature ...
Rafaa Chouder, Noureddine Benhamidouche
doaj   +1 more source