Results 31 to 40 of about 41,071 (268)

Secondary Flow near an Undulatory Surface Induced by Wall Blocking Effect

Journal of Fluid Science and Technology, 2007
Secondary mean motions of Prandtl's second kind near an undulatory surface are explained in terms of the turbulent blocking effect and kinematic boundary conditions at the surface, and the order of magnitude is estimated. The isotropic turbulence is
Kouji NAGATA, Peter A. DAVIDSON, Henry Y. W. WONG   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

α-Mean curvature flow of non-compact complete convex hypersurfaces and the evolution of level sets

Advances in Nonlinear Analysis
We consider the α\alpha -mean curvature flow for convex graphs in Euclidean space. Given a smooth, complete, strictly convex, non-compact initial hypersurface over a strictly convex projected domain, we derive uniform curvature bounds, which are ...
Kang Hyunsuk, Lee Ki-Ahm, Lee Taehun
doaj   +1 more source

A geometric flow on null hypersurfaces of Lorentzian manifolds

Topological Algebra and its Applications, 2022
We introduce a geometric flow on a screen integrable null hypersurface in terms of its local second fundamental form. We use it to give an alternative proof to the vorticity free Raychaudhuri’s equation for null hypersurface, as well as establishing ...
Massamba Fortuné, Ssekajja Samuel
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Comparison of lingual mucosa and buccal mucosa grafts used in inlay urethroplasty in failed hypospadias of pre-pubertal boys in a Chinese group. [PDF]

PLoS ONE, 2017
The purpose of this study was to compare the outcomes of the buccal mucosa and lingual mucosa used in children who received multiple failed hypospadias surgeries.We conducted a retrospective study of 62 children who received buccal or lingual mucosa ...
Jin Hongyong, Chen Shuzhu, Wu Min, Ye Weijing, Liu Yidong   +4 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

A New Algorithm for Calculating the Flow Path Curvature (C) from the Square-Grid Digital Elevation Model (DEM)

ISPRS International Journal of Geo-Information, 2020
This paper proposes a flow-path-network-based (FPN-based) algorithm, constructed from a square-grid digital elevation model (DEM) to improve the simulation of the flow path curvature (C).
Qianjiao Wu, Yumin Chen, Hongyan Zhou, Shujie Chen, Han Wang   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source