Results 121 to 130 of about 9,396,166 (289)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Liouville's theorem and the restricted mean property for Biharmonic Functions
Electronic Journal of Differential Equations, 2004 We prove that under certain conditions, a bounded Lebesgue measurable function satisfying the restricted mean value for biharmonic functions is constant, in $mathbb{R}^n$ with $nge 3$.
Mohamed El Kadiri
doaj
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Some generalized matrix means inequalities
AIMS MathematicsIn this paper, we will give some AM-GM-HM singular values inequalities and some weighted power mean inequalities, our results generalized and complete the existed ones.
Junmei Zuo, Yonghui Ren
doaj +1 more source
Mean Values ofL-Functions over Function Fields
Journal of Number Theory, 1997 The purpose of this paper is to study the average values of twists, by quadratic characters, of \(L\)-series associated with automorphic forms on \(GL_2\) over function fields. The method which the author develops here is the study of the Rankin-Selberg convolution of the form in question with an Eisenstein series on the metaplectic cover of \(GL_2 ...
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
On a mean value theorem connected with Hermite-Hadamard's inequality
Journal of Numerical Analysis and Approximation Theory, 2004 In this paper we prove a mean-value theorem for integral calculus, then we demonstrate properties of the mean point. In the end we give an extension of Hermite-Hadamard's inequality.
Ovidiu T. Pop
doaj +2 more sources