Results 81 to 90 of about 18,073,426 (243)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Enhancement of stability of metastable states in the presence of Lévy noise

SciPost Physics
The barrier-crossing event for superdiffusion characterized by symmetric Lévy flights is analyzed. Starting from the fractional Fokker-Planck equation, we derive an integro-differential equation along with the necessary conditions to calculate the mean ...
Alexander A. Dubkov, Claudio Guarcello, Bernardo Spagnolo
doaj   +1 more source

Rural-urban differences in the association between individual, facility, and clinical characteristics and travel time for cancer treatment

BMC Public Health, 2020
Background Greater travel time to cancer care has been identified as a potential barrier to care as well as associated with worse health outcomes. While rural cancer patients have been shown to travel farther for care, it is not known what patient ...
Joel E. Segel, Eugene J. Lengerich
doaj   +1 more source

Modeling the Mean Residence Time of Liquid Phase in the Gas–Liquid Cyclone

, 2015
Residence time is a key parameter for the cyclones with mass transfer or reaction process. A model for the cylinder-on-cone cyclone was presented to calculate the mean residence time of the liquid phase, based on a force balance on the wall film.
Xupeng Zhang (1493305), Youhai Jin (1493302), Guoping Shen (1294830), Junwei Yang (112231), Jiazhi Xiao (1294824)   +4 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Mean and maximum residence times, and mean square deviation of selected protein-bound waters.

, 2012
Only water molecules that are protein-bound in simulations F and are shown. The mean residence time, tmean(α) was calculated using eq.2. tmax is the maximum mean residence time at a particular hydration site.
Alemayehu A. Gorfe (182787), Priyanka Prakash (182776), Abdallah Sayyed-Ahmad (182780)   +2 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Human apolipoprotein A-I and A-II metabolism

Journal of Lipid Research, 1982
The kinetics of the major apolipoproteins (apo) of plasma high density lipoproteins (HDL), apoA-I and apoA-II, were examined in a total of 44 individual tracer studies in 22 normal male and female subjects.
E J Schaefer, L A Zech, L L Jenkins, T J Bronzert, E A Rubalcaba, F T Lindgren, R L Aamodt, H B Brewer, Jr   +7 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source