Results 51 to 60 of about 17,296,305 (235)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Phon Mean oral history recording
, 2001 An audio recording of an oral history of Phon Mean about fleeing Cambodia with her family at age ten and coming to the United States. She talks about life in Cambodia when she was a child and then about life in the U.S., including school, her first job ...
Mean, Phon
core +1 more source
Design and simulation of gas burner ejectors
Carbon Resources Conversion, 2021 Ignition within gas burner ejectors can lead to off design conditions and has significant influence on the burner behavior. Thus ignition in the ejector should be prevented. In the present study the influence of combustion reactions on the performance of
Mario Pichler +6 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Modeling the impacts of streambed sediment heterogeneity on hyporheic exchange
Shui kexue jinzhan, 2019 The hyporheic exchange plays a crucial role in maintaining fluvial ecological processes. In order to examine the influence of streambed heterogeneity on the hyporheic exchange,a surface water-groundwater coupling model is constructed for solving flow ...
CHEN Xiaobing, ZHENG Chunyang, YUAN Yue
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Factorial design to quantify the influence of extrusion parameters in the mean residence time
Polímeros, 2010 Residence time distribution (RTD) is a very important parameter in extrusion, either for simple polymer processing or for special processes like compounding, blending, reactive compatibilization, and controlled degradation.
Tomás J. A. de Mélo +2 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source