Results 71 to 80 of about 17,296,305 (235)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Review: Axial Motion of Material in Rotary Kilns

Eng
The article examines the parameters of axial motion of bulk material in rotary kilns, including bed height, axial velocity, and mean residence time.
Elmira Fedorova, Vladimir Morgunov, Kirill Lobko, Elena Pupysheva   +3 more
doaj   +1 more source

Mean Transit Time and Mean Residence Time for Linear Diffusion–Convection–Reaction Transport System [PDF]

Computational and Mathematical Methods in Medicine, 2007
Characteristic times for transport processes in biological systems may be evaluated as mean transit times (MTTs) (for transit states) or mean residence times (MRT) (for steady states). It is shown in a general framework of a (linear) reaction–diffusion–convection equation that these two times are related.
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Enhancement of stability of metastable states in the presence of Lévy noise

SciPost Physics
The barrier-crossing event for superdiffusion characterized by symmetric Lévy flights is analyzed. Starting from the fractional Fokker-Planck equation, we derive an integro-differential equation along with the necessary conditions to calculate the mean ...
Alexander A. Dubkov, Claudio Guarcello, Bernardo Spagnolo
doaj   +1 more source

Rural-urban differences in the association between individual, facility, and clinical characteristics and travel time for cancer treatment

BMC Public Health, 2020
Background Greater travel time to cancer care has been identified as a potential barrier to care as well as associated with worse health outcomes. While rural cancer patients have been shown to travel farther for care, it is not known what patient ...
Joel E. Segel, Eugene J. Lengerich
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Human apolipoprotein A-I and A-II metabolism

Journal of Lipid Research, 1982
The kinetics of the major apolipoproteins (apo) of plasma high density lipoproteins (HDL), apoA-I and apoA-II, were examined in a total of 44 individual tracer studies in 22 normal male and female subjects.
E J Schaefer, L A Zech, L L Jenkins, T J Bronzert, E A Rubalcaba, F T Lindgren, R L Aamodt, H B Brewer, Jr   +7 more
doaj   +1 more source