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Mean residence time: Some further consideration
Biopharmaceutics and Drug Disposition, 1989AbstractThe correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.
P S Collier
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Danckwerts’ law for mean residence time revisited
Chemical Engineering Science, 2006This paper shows that Danckwerts’ law for mean residence time in a vessel with continuous and steady through∞ow holds for a stochastic model based on a Markov chain for the particle spatial position, under a set of three very general conditions on the transfer probabilities.
Alex Christian Hoffmann
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Mean residence time and the meaning of AUMC/AUC
Biopharmaceutics and Drug Disposition, 1990exaly +3 more sources
Biopharmaceutics & Drug Disposition, 1988
AbstractMean residence times (MRTs) have been classified into two main groups, namely system moment MRT [MRT(S,MO] and system matrix MRT [MRT(S,MA]. There are also MRTs of individual compartments [MRT(i)] such as central or plasma compartment, [MRT(P)], and tissue compartments and the MRT of an absorption site, [MRT(A)].
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AbstractMean residence times (MRTs) have been classified into two main groups, namely system moment MRT [MRT(S,MO] and system matrix MRT [MRT(S,MA]. There are also MRTs of individual compartments [MRT(i)] such as central or plasma compartment, [MRT(P)], and tissue compartments and the MRT of an absorption site, [MRT(A)].
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The mean oceanic residence time
Marine Chemistry, 1982Abstract In this note the significance of heat of hydration and electronegativity in the study of oceanic residence times of elements is discussed.
Chen-Ping Chang +2 more
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Mean residence time in multicompartmental models with time delays
Journal of Biomedical Engineering, 1993Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any n-compartmental models which may ...
Y, Plusquellec, G, Houin
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On mean residence times in flow systems
Chemical Engineering Science, 1983Abstract A widely accepted result of residence time theory namely mean residence time is equal to the system volume divided by the flow rate was first offered by Danckwerts[l] and later extended by Buffham[21 and Gibilaro[3] to more general cases.
R.C. Awasthi, K. Vasudeva
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Mean residence time of plutonium in the troposphere
Environmental Science & Technology, 1982Plutonium is injected into the stratosphere by large atmospheric thermonuclear explosions. When aerosols bearing plutonium reenter the troposphere, they are removed by such processes as rainfall and sedimentation. In this work, the mean tropospheric residence time of stratospherically injected plutonium is calculated.
Robert W. Holloway, David W. Hayes
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Methods and findings in experimental and clinical pharmacology, 1986
The definition of mean residence time in the strict sense of mathematical statistics is deduced. It is demonstrated that the area-normalized concentration time curve is an estimate of the probability density function for residence times of drug molecules in the pharmacokinetic system, provided that the area under the concentration-time profile is ...
D, Brockmeier, H M, von Hattingberg
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The definition of mean residence time in the strict sense of mathematical statistics is deduced. It is demonstrated that the area-normalized concentration time curve is an estimate of the probability density function for residence times of drug molecules in the pharmacokinetic system, provided that the area under the concentration-time profile is ...
D, Brockmeier, H M, von Hattingberg
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Mean residence time for drugs subject to enterohepatic cycling
Journal of Pharmacokinetics and Biopharmaceutics, 1989A physiologically realistic model of enterohepatic cycling (EHC) which includes separate liver and gallbladder compartments, discontinuous gallbladder emptying and first-order absorption from both an oral formulation and secreted bile (kapo and kab, respectively) has been developed.
Shepard, Theresa A. +3 more
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