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Mean residence time in organs in toxicokinetic studies

Mean residence time in organs in toxicokinetic studies
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Mean residence time in the body versus mean residence time in the central compartment

Journal of Pharmacokinetics and Biopharmaceutics, 1985
Mean residence time in the body may be determined by noncompartmental methods following any type of input process into the sampled compartment. Mean residence time in the central compartment can be determined following an intravenous bolus dose, as it requires calculation of the concentration at zero time. For any other input process the mean residence
Leslie Z Benet, Benet Leslie Z
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Definition of mean residence times in pharmacokinetics

Biopharmaceutics & Drug Disposition, 1987
AbstractA new definition of the mean residence time is proposed which includes the commonly used definition as a special case. The advantage of the new definition is that it applies for both linear and non‐linear systems. Some practical advantages which follow from the new definition are discussed.
D J Cutler
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Mean residence time in peripheral tissue

Journal of Pharmacokinetics and Biopharmaceutics, 1987
The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.
P J, McNamara, J C, Fleishaker, T L, Hayden   +2 more
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Comments on mean residence time determination

Journal of Pharmacokinetics and Biopharmaceutics, 1985
In a recent paper, D. O. Chanter challenged the applicability of the use of statistical moments in estimating mean residence time and proposed an alternative approach. Errors in that paper are pointed out which involve the improper equating of whole-body amount of drug with plasma amount of drug in a kinetic system.
E M, Landaw, D, Katz
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Mean residence time: Some further consideration

Biopharmaceutics & Drug Disposition, 1989
AbstractThe correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.
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Danckwerts’ law for mean residence time revisited

Chemical Engineering Science, 2006
This paper shows that Danckwerts’ law for mean residence time in a vessel with continuous and steady through∞ow holds for a stochastic model based on a Markov chain for the particle spatial position, under a set of three very general conditions on the transfer probabilities.
Timo Gottschalk, Herold G. Dehling, Alex C. Hoffmann   +2 more
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Mean residence time and the meaning of AUMC/AUC

Biopharmaceutics & Drug Disposition, 1990
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The mean oceanic residence time

Marine Chemistry, 1982
Abstract In this note the significance of heat of hydration and electronegativity in the study of oceanic residence times of elements is discussed.
Chen-Ping Chang, Lian-Sen Liu, Chen-Tung Chen   +2 more
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