Results 221 to 230 of about 259,559 (260)

Comments on mean residence time determination

Journal of Pharmacokinetics and Biopharmaceutics, 1985
In a recent paper, D. O. Chanter challenged the applicability of the use of statistical moments in estimating mean residence time and proposed an alternative approach. Errors in that paper are pointed out which involve the improper equating of whole-body amount of drug with plasma amount of drug in a kinetic system.
E M, Landaw, D, Katz
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The mean oceanic residence time

Marine Chemistry, 1982
Abstract In this note the significance of heat of hydration and electronegativity in the study of oceanic residence times of elements is discussed.
Chen-Ping Chang, Lian-Sen Liu, Chen-Tung Chen   +2 more
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Mean residence time in multicompartmental models with time delays

Journal of Biomedical Engineering, 1993
Calculation of the mean residence time (MRT) of a drug in a stationary compartmental model is classically carried out from several expressions. Nevertheless, one or more time delays between compartments modify the mean residence times. It is the aim of this paper to propose a general method for MRT calculations, in any n-compartmental models which may ...
Y, Plusquellec, G, Houin
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On mean residence times in flow systems

Chemical Engineering Science, 1983
Abstract A widely accepted result of residence time theory namely mean residence time is equal to the system volume divided by the flow rate was first offered by Danckwerts[l] and later extended by Buffham[21 and Gibilaro[3] to more general cases.
R.C. Awasthi, K. Vasudeva
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Mean residence time of plutonium in the troposphere

Environmental Science & Technology, 1982
Plutonium is injected into the stratosphere by large atmospheric thermonuclear explosions. When aerosols bearing plutonium reenter the troposphere, they are removed by such processes as rainfall and sedimentation. In this work, the mean tropospheric residence time of stratospherically injected plutonium is calculated.
Robert W. Holloway, David W. Hayes
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Mean residence time.

Methods and findings in experimental and clinical pharmacology, 1986
The definition of mean residence time in the strict sense of mathematical statistics is deduced. It is demonstrated that the area-normalized concentration time curve is an estimate of the probability density function for residence times of drug molecules in the pharmacokinetic system, provided that the area under the concentration-time profile is ...
D, Brockmeier, H M, von Hattingberg
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Mean residence time for drugs subject to enterohepatic cycling

Journal of Pharmacokinetics and Biopharmaceutics, 1989
A physiologically realistic model of enterohepatic cycling (EHC) which includes separate liver and gallbladder compartments, discontinuous gallbladder emptying and first-order absorption from both an oral formulation and secreted bile (kapo and kab, respectively) has been developed.
Shepard, Theresa A., Lockwood, Graham F., Aarons, Leon J.; id_orcid 0000-0003-2704-6570, Abrahams, I. David   +3 more
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Mean residence time: Some further consideration

Biopharmaceutics & Drug Disposition, 1989
AbstractThe correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.
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Sampling strategies for noncompartmental estimation of mean residence time

Journal of Pharmacokinetics and Biopharmaceutics, 1983
An optimization procedure is presented for selecting sample times for estimating mean residence time using noncompartmental data analysis. Performance of this experimental design strategy is evaluated using Monte Carlo simulations of a model for digoxin kinetics.
D Z, D'Argenio, D, Katz
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Residence Times and Mean Concentrations

1985
The residence time T of a single particle is the time spent in the atmosphere of that particle. From the definitions in section 3 it follows that $$ E(c(t))\, = \,\int\limits_{ - \infty }^t {E(e^{ - (\Lambda (t) - \Lambda (s))} dq(s))} . $$
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