Results 131 to 140 of about 428,360 (302)

Semiparametric Regression Analysis of Mean Residual Life with Censored Survival Data

open access: yes
As a function of time t, mean residual life is the remaining life expectancy of a subject given survival up to t. The proportional mean residual life model, proposed by Oakes & Dasu (1990), provides an alternative to the Cox proportional hazards model to
Su-Chun Cheng, Ying Chen
core   +2 more sources

Generalizing Uncertainty Through Dynamic Development and Analysis of Residual Cumulative Generalized Fractional Extropy with Applications in Human Health

open access: yesFractal and Fractional
The complementary dual of entropy has received significant attention in the literature. Due to the emergence of many generalizations and extensions of entropy, the need to generalize the complementary dual of uncertainty arose.
Mohamed Said Mohamed, Hanan H. Sakr
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

On generalized mean residual life of record values

open access: yes
The mean residual life function plays an important role in reliability theory and other branches of statistics. In this paper, we study some ageing properties of the residual life of , the nth upper k-records, given that , where n[greater-or-equal ...
Kundu, Chanchal, Nanda, Asok K.
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Trend changes in failure rate and mean residual life: Its relations and applications

open access: yes, 1995
The classes of life distributions which exhibit the trend change in its aging properties, such as failure rate, mean residual life, have attracted a great deal of interest among the reliability analysts and engineers.
Nam, Kyung Hyun
core  

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