Results 171 to 180 of about 428,360 (302)

Nonparametric estimation of bivariate mean residual life function

, 2005
In survival analysis the additional lifetime that an object survives past a time t is called the residual life function of the object. Mathematically speaking if the lifetime of the object is described by a random variable T then the random variable R(t)
Ghebremichael, Musie S.
core  

Seasonal metabolic and growth responses of grazing beef heifers divergent in residual feed intake. [PDF]

PLoS One
Londono-Mendez MC, Lasso-Ramirez S, Fitzsimmons C, Plastow G, Bork EW, Basarab J, Vasco ACCM, Silva AEM, Macias Franco A, Vinsky M, Li C, Medeiros da Silva G.   +11 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Residual Angina Following Complete Revascularization in the ISCHEMIA Trial: Frequency, Clinical Characteristics, Health Status, and Cardiovascular Outcomes. [PDF]

J Am Heart Assoc
Singh A, Brown DL, Jones PG, Fu Z, Reynolds HR, Boden WE, O'Brien SM, Mavromatis K, Poh KK, Ali Z, Stone GW, Bangalore S, Spertus JA, Maron DJ, Hochman JS, ISCHEMIA Research Group.   +15 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Oral health-related quality of life after early extraction of primary second molars in children with congenitally missing second premolars: a randomized controlled trial with matched controls. [PDF]

Eur J Orthod
Naoumova J, Nawaia S, Krekmanova L.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Two Parameter Discrete Lindley Distribution

Revista Colombiana de Estadística
In this article we have proposed and discussed a two parameter discrete Lindley distribution. The derivation of this new model is based on a two step methodology i.e.
TASSADDAQ HUSSAIN, MUHAMMAD ASLAM, MUNIR AHMAD   +2 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Variance-Guided Regression for Heteroscedastic Data With a Grouping-Based Extension for Nonlinear Prediction. [PDF]

Stat Med
Liu S, Lu M.
europepmc   +1 more source