Results 91 to 100 of about 291,506 (257)

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Properties and Applications of A New Attractive Distribution

Journal of Statistical Theory and Applications (JSTA)
We provide a new, flexible model called the Odd Kappa-Exponential (OK-E) distribution. The shape of its hazard rate function (hrf) might be constant, declining, growing, inverted-J, bathtub, or inverted-bathtub. The probability density function (pdf) and
Ali A. Al-Shomrani, Ahmed Al-Arfaj
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modeling to COVID-19 and cancer data: Using the generalized Burr-Hatke model

Journal of Radiation Research and Applied Sciences
This paper describes an extended version of the Burr–Hatke distribution via generalizing its survival function. This model is called as the generalized Burr-Hatke distribution. The suggested model's hazard rate function can be non-increasing (decreasing)
Ibrahim E. Ragab, Sadaf Khan, Najwan Alsadat, Farrukh Jamal, Gholamhossein G. Hamedani, Mohammed Elgarhy   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Sinusoidal exponential distribution for modeling elevated creatinine kinase level as the initial presentation of Covid-19

Scientific Reports
This paper is devoted to deriving a new lifetime distribution based on a sine function to model different initial symptoms of Covid-19 patients that initially present as muscle weakness with increased Creatinine Kinase (CK), without fever or respiratory ...
N. M. Kilany, A. M. Alharpy
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

ON THE MOMENTS OF THE 3-PARAMETER GOMPERTZ DISTRIBUTION

Barekeng
Gompertz distribution is a classical probability distribution extensively used in actuarial science, reliability, and survival analysis. Gompertz distribution also plays a role in various fields, such as biology, economics, and marketing analysis.
Moch Taufik Hakiki, Dimaz Wisnu Adipradana, Imam Safawi Ahmad, Lahfanda Dista Permata Putri   +3 more
doaj   +1 more source