Results 211 to 220 of about 294,527 (276)

Antenatal Maternal Smoking and Lung Function in Very Prematurely Born Children. [PDF]

Pediatr Pulmonol
Jenkinson A, Zivanovic S, Harris C, Dassios T, Greenough A.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Characteristics and prognostic significance of right atrium remodeling and tricuspid regurgitation after balloon pulmonary angioplasty-application value of echocardiography. [PDF]

BMC Cardiovasc Disord
Ma Y, Guo D, Wang J, Zhang X, Hu H, Wang Y, Yang Y, Lv X, Gong J, Li Y.   +9 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Association between hemoglobin glycation index and cognitive function: Evidence in the elderly. [PDF]

PLoS One
Ge L, Guo Y, Xu X, Xu J, Hu M.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Residual Angina Following Complete Revascularization in the ISCHEMIA Trial: Frequency, Clinical Characteristics, Health Status, and Cardiovascular Outcomes. [PDF]

J Am Heart Assoc
Singh A, Brown DL, Jones PG, Fu Z, Reynolds HR, Boden WE, O'Brien SM, Mavromatis K, Poh KK, Ali Z, Stone GW, Bangalore S, Spertus JA, Maron DJ, Hochman JS, ISCHEMIA Research Group.   +15 more
europepmc   +1 more source

Residual-Based Sieve Maximum Full Likelihood Estimation for the Proportional Hazards Model. [PDF]

Commun Stat Theory Methods
Choi T, Halabi S, Kim H, Wu Y.
europepmc   +1 more source

Cognitive Dysfunction and Vascular/Valvular Calcification in Patients Undergoing Peritoneal Dialysis: A Cross-Sectional Study. [PDF]

J Clin Med
Şensoy NNÖ, Usta M, Coşar S, Urfalı FE, Koruk D, Bekirçavuşoğlu S, Emre T.   +6 more
europepmc   +1 more source