Results 51 to 60 of about 4,553,284 (282)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Evaluation of SSM-Wheat Model in Simulating the Growth and Development of Wheat (Triticum aestivum L.) Cultivars in Different Planting Densities [PDF]
بوم شناسی کشاورزیIntroductionWheat (Triticum aestivum L.) is one of the most important and widely consumed crops in the world. Changing the density towards an optimal density can alter the ratio of soil evaporation to plant transpiration in such a way that water use ...
Ali Rahemi karizki +5 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Enhanced q-least Mean Square [PDF]
Circuits, Systems, and Signal Processing, 2019 In this work, a new class of stochastic gradient algorithm is developed based on $q$-calculus. Unlike the existing $q$-LMS algorithm, the proposed approach fully utilizes the concept of $q$-calculus by incorporating time-varying $q$ parameter.
Alishba Sadiq +4 more
openaire +2 more sources
Enumeration of self-avoiding walks on the square lattice
, 2004 We describe a new algorithm for the enumeration of self-avoiding walks on the square lattice. Using up to 128 processors on a HP Alpha server cluster we have enumerated the number of self-avoiding walks on the square lattice to length 71.
Caracciolo S +23 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Two sharp double inequalities for Seiffert mean
Journal of Inequalities and Applications, 2011 In this paper, we establish two new inequalities between the root-square, arithmetic, and Seiffert means. The achieved results are inspired by the paper of Seiffert (Die Wurzel, 29, 221-222, 1995), and the methods from Chu et al. (J. Math.
Gong Wei-Ming +2 more
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Distributed Incremental Least Mean-Square for Parameter Estimation using Heterogeneous Adaptive Networks in Unreliable Measurements [PDF]
Journal of Artificial Intelligence and Data Mining, 2017 Adaptive networks include a set of nodes with adaptation and learning abilities for modeling various types of self-organized and complex activities encountered in the real world.
M. Farhid, M. Shamsi, M. H. Sedaaghi
doaj +1 more source