Results 81 to 90 of about 4,553,284 (282)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Robustness of mean-square exponential dichotomies for linear stochastic equations

open access: yesElectronic Journal of Differential Equations, 2017
We present the notion of mean-square exponential dichotomies for linear stochastic differential equations. We study the robustness of the mean-square exponential dichotomies, in the sense of the existence of a mean-square exponential dichotomy for a ...
Hailong Zhu, Yongxin Jiang
doaj  

Mean-square heterogeneous synchronization of interdependent networks with stochastic disturbances

open access: yesAdvances in Difference Equations, 2019
In this paper, the mean-square asymptotical heterogeneous synchronization of interdependent networks with stochastic disturbances, which is a zero-mean real Wiener process, is investigated.
Tianjiao Guo, Lilan Tu, Jiabo Chen
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Measured and predicted root-mean-square errors in square and triangular antenna mesh facets [PDF]

open access: yes
Deflection shapes of square and equilateral triangular facets of two tricot-knit, gold plated molybdenum wire mesh antenna materials were measured and compared, on the basis of root mean square (rms) differences, with deflection shapes predicted by ...
Fichter, W. B.
core   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Exact Mean Integrated Squared Error

open access: yesThe Annals of Statistics, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Marron, J. S., Wand, M. P.
openaire   +3 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Exploring novel antitubercular agents: Innovative design of 2,3-diaryl-quinoxalines targeting DprE1 for effective tuberculosis treatment

open access: yesOpen Chemistry
The rising instances of drug resistance in Mycobacterium tuberculosis strains pose a significant global health challenge. Conventional tuberculosis (TB) treatments, which typically involve multiple antibiotics, face hurdles like drug resistance, reduced ...
Sharma Kirti   +8 more
doaj   +1 more source

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