Results 161 to 170 of about 904,656 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Navigating the mysterious space of evolutionary histories. [PDF]

Proc Natl Acad Sci U S A
Drummond AJ, Popinga A.
europepmc   +1 more source

On designing dependable services with diverse off-the-shelf SQL servers [PDF]

, 2004
A. Avizienis, A. Avizienis, A. Vaysburd, B. Kemme, C. Babbage, D. Powell, F. Pedone, F. Schneider, I. Gashi, J. Gray, J. Gray, J.C. Laprie, M. Patino-Martinez, M. Weismann, P. Popov, P.A. Bernstein, P.E. Ammann, P.J. Traverse, P.M. Chen, R. Jimenez-Peris, R. Jimenez-Peris, S. Chandra, S. Chandra, S. Poledna, S. Poledna, T. Anderson   +25 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Clinical Outcomes Following Revision Cochlear Implantation: A Single-Center Experience. [PDF]

Turk Arch Otorhinolaryngol
Dalğıç A, Kertmen C, Aydın E, Yaramış HB.   +3 more
europepmc   +1 more source

Reliability study on avionics: feasibility study to determine mean time between failure (MTBF)

, 2020
No momento presente o mundo enfrenta um aumento na pressão para que os trabalhos se executem de modo mais rápido, melhor e mais barato, exigindo que os engenheiros prevejam com precisão a fiabilidade dos produtos. Nas fases iniciais do processo de design do produto, essas previsões precisas contribuirão não só para um produto mais robusto e fiável, mas
openaire   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Synaptic Facilitation Enhances the Reliability and Precision of High-Frequency Neurotransmission. [PDF]

J Neurosci
Bernal-Correa AM, Dagostin A, von Gersdorff H, Kushmerick C.   +3 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Safety and Survival Rate of a Biomimetic Osteochondral Scaffold for the Treatment of Lesions of the Knee Articular Surface. [PDF]

Orthop J Sports Med
Andriolo L, De Marziani L, Di Martino A, Boffa A, Zanasi L, Roveda G, Miale R, Zaffagnini S.   +7 more
europepmc   +1 more source