Results 211 to 220 of about 13,410,624 (245)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Correction: The incremental predictive value of biological aging indicators for cognitive impairment in older adults: a longitudinal analysis on the Mr. OS & Ms. OS cohort. [PDF]

Alzheimers Res Ther
Wu Y, Zhang T, Auyeung TW, Lee J, Leung J, Kwok T.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Audiological Profile and Factors Associated With Hearing Impairment Among Adults With Allergic Rhinitis in Tamil Nadu, India: A Hospital-Based Cross-Sectional Study. [PDF]

Cureus
V HV, George NS, G AK, Mohandas NV, I T.
europepmc   +1 more source

The Effect of Lactoferrin and Magnesium Phosphate Hydrogel Coating on Osteoblast Activity on Titanium Discs: An In Vitro Study. [PDF]

Cureus
Patni K, J S, Kumar U K.
europepmc   +1 more source

Returning an extirpated native carnivore to its former range: a habitat suitability analysis of Kangaroo Island for spotted-tailed quolls (Dasyurus maculatus). [PDF]

Sci Rep
Retallack M, Ostendorf B, Fancourt B, Peacock D.   +3 more
europepmc   +1 more source

Gameful Experience and Perceived Educational Value in a Student-Designed Medical Escape Room for Preclinical Medical Education: Cross-Sectional Study. [PDF]

JMIR Serious Games
Dafli E, Kountouratzis I, Doufexi I, Nikolaidis A, Kourpanidis A, Koniaris O, Kyriakidis N, Nikolaidou M, Gilou S, Antoniou P, Bamidis PD.   +10 more
europepmc   +1 more source

A Tri-Direction Guided Moss Growth Optimizer with Adaptive Differential Evolution for Engineering Design Problems. [PDF]

Biomimetics (Basel)
Pang C, Wang Y, Cheng W.
europepmc   +1 more source