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Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
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Meaning by means of meaning? by no means!

Erkenntnis, 1975
Analyses of what it is for an utterance-type to have meaning in a language may, as those of Grice1, Lewis2, Schiffer3, and Bennett4, try to start from what it is for a speaker to mean something by an utterance. If they analyse this latter concept completely in terms of the speaker's intentions as the authors cited do they arrive at something like a gap
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On Meaning, Meaning and Meaning

2005
AbstractTo understand how language works, one must first look to the cooperative functions that various language forms perform, understanding these on a biological model as what these forms accomplish that keeps them in circulation. Next, one should look at language mechanics, at how language forms perform their functions, and especially to the ...
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The Meaning of Meaning

2020
That we must address the issue of what it means for something to mean something else shows in itself that the answer is not obvious. Indeed, philosophers of language spend the better part of their time on this very question. At the same time, the simplest man can use language and he knows just exactly what he means by the things that he says.
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Means and Means of Means

2009
We shall confine ourselves to unweighted and weighted arithmetic means as issued by the method of least squares.
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The Meanings of “Meaning”

Philosophy of Science, 1941
The following analysis has been undertaken mainly for the purpose of presenting a sample of a method which, as the writer holds, would, if widely and consistently applied, tend considerably to reduce the number and the significance of epistemological problems.
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Meaning to Mean It

1994
Abstract Murti Pujak Jains insist that it is necessary that one means to mean. This idea was acknowledged by virtually all our informants at the Dadabari temple. At the same time however, there was no confidence that not having meant disqualifies the/?w/« as a, puja.
Caroline Humphrey, James Laidlaw
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The Meaning of Means

2016
In the last chapter we used the Markov–Kakutani Theorem to produce for every compact abelian group G an “invariant mean”: a mean in the algebraic dual space of B(G) fixed by the adjoint of every translation map on B(G). The Riesz Representation Theorem then provided a G-invariant, regular, Borel probability measure to represent this mean via ...
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On the meaning of "but".

Science of Computer Programming, 1991
In this paper, a formalization of exceptions to a general rule is proposed. It builds upon the modularisation of theories proposed by the algebraic specification approach, and preserves its engineering principles: modularity and com- positionality. It relies on a model-theoretic definition of the "but" conjunctive, whose properties and implementations ...
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