Results 141 to 150 of about 243,984 (315)
Medical Sciences ForumPurpose in life is a central component of healthy ageing and psychological well-being, yet its meaning in later life has often been operationalised through standardized measures rather than being grounded in older adults’ lived experience.
Alejandra Chulian +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Prior research documents strong associations between an increased sense of purpose/meaning in life with improved health and well-being outcomes. However, less is known about how levels of purpose/meaning in life differ across cultures and across ...
R. Noah Padgett +7 more
core +1 more source
Exploring Frankl’s meaning, purpose and value of life in Malaysian university students
, 2019 This study has been using the Logotherapy approach, a therapy introduced by Viktor Frankl that emphasizes the meaning, purpose and value of life. Frankl’s concept of purpose in life is based on a religious existential foundation which postulated that
Adnan, Zatul Himmah +4 more
core +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Meaning, purpose, and narrative [PDF]
According to many philosophers, “the meaning of life” refers to our cosmic purpose, the activity that we were created by God or a purposive universe to perform. If there is no God or teleology, there is no such thing as the meaning of life. But this need
Zhao, Michael
core +3 more sources
Analyzing the View of Retirees About the Meanings, Meaningful Indicators and Demeaning of Life [PDF]
مسائل اجتماعی ایرانThe question of the meaning and purpose of life is one of the most worrying issues of the present age. So that many theorists believe that finding the meaning of life is one of the most important needs of humans today.
Mazhar Babaee +2 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source