Results 181 to 190 of about 243,984 (315)

What Psychiatry Measures, and What It Misses: Flourishing as a Blind Spot in Patient-Centered Care. [PDF]

Harv Rev Psychiatry
VanderWeele TJ, Haque OS, Peteet JR.
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Reconceptualizing Purpose in the Third Age: From Linear Accumulation to Present-Centred Sufficiency? [PDF]

Psychol Res Behav Manag
Han J.
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A Context-Informed Evolutionary Concept Analysis of Ikigai in Later Life: Evidence Relevant to Older People in Korea. [PDF]

Int J Older People Nurs
Chang H, Seo J, Park M, Do Y.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Visual art experience and psychological distress among university students: parallel indirect effects through presence and search for meaning. [PDF]

Front Public Health
Lv H.
europepmc   +1 more source

The Fake Purpose of Life: Coherence, Delusion, and the Kernel of Meaning

This paper examines the distinction between the fake purposes that capture human attention—status, identity, consumption, tribalism—and the true purpose of life understood as convergence to coherence, love, and freedom. Drawing on predictive processing, neuroscience, and kernel-based alignment theory, we propose that hallucinations in machines and ...
openaire   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Purpose in life and mortality: A meta-analysis of the published literature and individual-participant data of 488,765 participants followed for up to 32 years. [PDF]

Psychol Med
Sutin A, Zavala D, Milad E, Stephan Y, Karakose S, Brown J, Terracciano A, Luchetti M.   +7 more
europepmc   +1 more source