Results 231 to 240 of about 243,984 (315)

The relationship between smartphone addiction and academic burnout among physical education teacher students: a chain mediating of meaning in life and physical exercise. [PDF]

Front Psychol
Ma H, Liu L, Liu T, Huang S, Yin Z, Cheng W.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Daily Meaning in Life Buffers the Within-Person Relationships Between Perceived Burdensomeness and Thwarted Belongingness With Next-Day Suicidal Ideation: An Ecological Momentary Assessment Study. [PDF]

Suicide Life Threat Behav
Cenkner DP, Duan A, Horwitz AG, Vijayakumar KSM, Odgers CL, Burgess HJ, Zalta AK.   +6 more
europepmc   +1 more source

Meaning in life and personal purpose: a new challenge for organisations?

The meaning of life is a growing concept in recent years. Among the multiple meanings it presents, purpose is the one that has shown the greatest interest to a greater extent. Understanding that the professional level is a substantial part of the vital exercise of people, this article analyzes if the scientific production related to the field of ...
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Loneliness, Depression, and Subjective Memory Complaints in Middle-Aged and Older Adults: The Role of Meaning in Life. [PDF]

Psychiatry Investig
Lee SC, Cho S, Shim Y, Yun DH, Kim T, Noh SR.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Correction: Systematic review of search for meaning in life assessment tools: highlighting the need for a quest for significance scale. [PDF]

Front Psychol
Alsaadi F, Maldonado MA, Erfanikia M, Molinario E, Moyano M.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source